Eosinophilic Chronic Obstructive Pulmonary Disease

Recent therapeutic advances in the management of asthma have underscored the importance of eosinophilia and the role of pro-eosinophilic mediators such as IL-5 in asthma. Given that a subset of patients with COPD may display peripheral eosinophilia similar to what is observed in asthma, a number of...

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Detalles Bibliográficos
Autores principales: Weissler, Jonathan C., Adams, Traci N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
State of the Art Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626390/
https://www.ncbi.nlm.nih.gov/pubmed/34739571
http://dx.doi.org/10.1007/s00408-021-00492-0
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author Weissler, Jonathan C.
Adams, Traci N.
author_facet Weissler, Jonathan C.
Adams, Traci N.
author_sort Weissler, Jonathan C.
collection PubMed
description Recent therapeutic advances in the management of asthma have underscored the importance of eosinophilia and the role of pro-eosinophilic mediators such as IL-5 in asthma. Given that a subset of patients with COPD may display peripheral eosinophilia similar to what is observed in asthma, a number of recent studies have implied that eosinophilic COPD is a distinct entity. This review will seek to contrast the mechanisms of eosinophilia in asthma and COPD, the implications of eosinophilia for disease outcome, and review current data regarding the utility of peripheral blood eosinophilia in the management of COPD patients.
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spelling pubmed-86263902021-12-01 Eosinophilic Chronic Obstructive Pulmonary Disease Weissler, Jonathan C. Adams, Traci N. Lung State of the Art Review Recent therapeutic advances in the management of asthma have underscored the importance of eosinophilia and the role of pro-eosinophilic mediators such as IL-5 in asthma. Given that a subset of patients with COPD may display peripheral eosinophilia similar to what is observed in asthma, a number of recent studies have implied that eosinophilic COPD is a distinct entity. This review will seek to contrast the mechanisms of eosinophilia in asthma and COPD, the implications of eosinophilia for disease outcome, and review current data regarding the utility of peripheral blood eosinophilia in the management of COPD patients. Springer US 2021-11-05 2021 /pmc/articles/PMC8626390/ /pubmed/34739571 http://dx.doi.org/10.1007/s00408-021-00492-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle State of the Art Review
Weissler, Jonathan C.
Adams, Traci N.
Eosinophilic Chronic Obstructive Pulmonary Disease
title Eosinophilic Chronic Obstructive Pulmonary Disease
title_full Eosinophilic Chronic Obstructive Pulmonary Disease
title_fullStr Eosinophilic Chronic Obstructive Pulmonary Disease
title_full_unstemmed Eosinophilic Chronic Obstructive Pulmonary Disease
title_short Eosinophilic Chronic Obstructive Pulmonary Disease
title_sort eosinophilic chronic obstructive pulmonary disease
topic State of the Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626390/
https://www.ncbi.nlm.nih.gov/pubmed/34739571
http://dx.doi.org/10.1007/s00408-021-00492-0
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