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Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report
Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626431/ https://www.ncbi.nlm.nih.gov/pubmed/34836998 http://dx.doi.org/10.1038/s41598-021-02269-0 |
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author | Bhullar, Amritpal S. Rivas-Serna, Irma Magaly Anoveros-Barrera, Ana Dunichand-Hoedl, Abha Bigam, David Khadaroo, Rachel G. McMullen, Todd Bathe, Oliver Putman, Charles T. Baracos, Vickie Clandinin, Michael T. Mazurak, Vera C. |
author_facet | Bhullar, Amritpal S. Rivas-Serna, Irma Magaly Anoveros-Barrera, Ana Dunichand-Hoedl, Abha Bigam, David Khadaroo, Rachel G. McMullen, Todd Bathe, Oliver Putman, Charles T. Baracos, Vickie Clandinin, Michael T. Mazurak, Vera C. |
author_sort | Bhullar, Amritpal S. |
collection | PubMed |
description | Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720–800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11–10.87), p = 0.03], EPA [HR 3.92 (1.1–14.0), p = 0.04] and DHA [HR 4.08 (1.1–14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer. |
format | Online Article Text |
id | pubmed-8626431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86264312021-11-29 Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report Bhullar, Amritpal S. Rivas-Serna, Irma Magaly Anoveros-Barrera, Ana Dunichand-Hoedl, Abha Bigam, David Khadaroo, Rachel G. McMullen, Todd Bathe, Oliver Putman, Charles T. Baracos, Vickie Clandinin, Michael T. Mazurak, Vera C. Sci Rep Article Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720–800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11–10.87), p = 0.03], EPA [HR 3.92 (1.1–14.0), p = 0.04] and DHA [HR 4.08 (1.1–14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer. Nature Publishing Group UK 2021-11-26 /pmc/articles/PMC8626431/ /pubmed/34836998 http://dx.doi.org/10.1038/s41598-021-02269-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Bhullar, Amritpal S. Rivas-Serna, Irma Magaly Anoveros-Barrera, Ana Dunichand-Hoedl, Abha Bigam, David Khadaroo, Rachel G. McMullen, Todd Bathe, Oliver Putman, Charles T. Baracos, Vickie Clandinin, Michael T. Mazurak, Vera C. Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
title | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
title_full | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
title_fullStr | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
title_full_unstemmed | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
title_short | Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
title_sort | depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626431/ https://www.ncbi.nlm.nih.gov/pubmed/34836998 http://dx.doi.org/10.1038/s41598-021-02269-0 |
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