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Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction
Found across all kingdoms of life, 2-keto acid dehydrogenase complexes possess prominent metabolic roles and form major regulatory sites. Although their component structures are known, their higher-order organization is highly heterogeneous, not only across species or tissues but also even within a...
Autores principales: | Tüting, Christian, Kyrilis, Fotis L., Müller, Johannes, Sorokina, Marija, Skalidis, Ioannis, Hamdi, Farzad, Sadian, Yashar, Kastritis, Panagiotis L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626477/ https://www.ncbi.nlm.nih.gov/pubmed/34836937 http://dx.doi.org/10.1038/s41467-021-27287-4 |
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