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Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness

Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely unknown. In this study, we identify that lysy...

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Detalles Bibliográficos
Autores principales:	Li, Rongkun, Li, Hengchao, Zhu, Lili, Zhang, Xiaoxin, Liu, Dejun, Li, Qing, Ni, Bo, Hu, Lipeng, Zhang, Zhigang, Zhang, Yanli, Wang, Xu, Jiang, Shu-Heng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626482/ https://www.ncbi.nlm.nih.gov/pubmed/34836938 http://dx.doi.org/10.1038/s41419-021-04391-3

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