CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose and lipid fluxes and severe comorbidities including cardiovascular disease and steatohepatitis. Whole body metabolism is regulated by lipid-storing white adipocytes as well as “brown” and “brite/beige” adipocyt...

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Detalles Bibliográficos
Autores principales: Tsagkaraki, Emmanouela, Nicoloro, Sarah M., DeSouza, Tiffany, Solivan-Rivera, Javier, Desai, Anand, Lifshitz, Lawrence M., Shen, Yuefei, Kelly, Mark, Guilherme, Adilson, Henriques, Felipe, Amrani, Nadia, Ibraheim, Raed, Rodriguez, Tomas C., Luk, Kevin, Maitland, Stacy, Friedline, Randall H., Tauer, Lauren, Hu, Xiaodi, Kim, Jason K., Wolfe, Scot A., Sontheimer, Erik J., Corvera, Silvia, Czech, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626495/
https://www.ncbi.nlm.nih.gov/pubmed/34836963
http://dx.doi.org/10.1038/s41467-021-27190-y

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