Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Primary brain tumors, such as glioblastoma (GBM), are remarkably resistant to immunotherapy, even though pre-clinical models suggest effectiveness. To understand this better in patients, here we take advantage of our recent neoadjuvant treatment paradigm to map the infiltrating immune cell landscape...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Alexander H., Sun, Lu, Mochizuki, Aaron Y., Reynoso, Jeremy G., Orpilla, Joey, Chow, Frances, Kienzler, Jenny C., Everson, Richard G., Nathanson, David A., Bensinger, Steven J., Liau, Linda M., Cloughesy, Timothy, Hugo, Willy, Prins, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626557/
https://www.ncbi.nlm.nih.gov/pubmed/34836966
http://dx.doi.org/10.1038/s41467-021-26940-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626557/
https://www.ncbi.nlm.nih.gov/pubmed/34836966
http://dx.doi.org/10.1038/s41467-021-26940-2

Ejemplares similares