Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy

Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different conce...

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Detalles Bibliográficos
Autores principales: Nakayama, Masao, Akasaka, Hiroaki, Miyazaki, Eiichi, Goto, Yoshihiro, Oki, Yuya, Kawate, Yosuke, Morita, Kenta, Sasaki, Ryohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626564/
https://www.ncbi.nlm.nih.gov/pubmed/34869923
http://dx.doi.org/10.1016/j.phro.2021.11.003
Descripción
Sumario:Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes.

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