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Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different conce...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626564/ https://www.ncbi.nlm.nih.gov/pubmed/34869923 http://dx.doi.org/10.1016/j.phro.2021.11.003 |
_version_ | 1784606680645894144 |
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author | Nakayama, Masao Akasaka, Hiroaki Miyazaki, Eiichi Goto, Yoshihiro Oki, Yuya Kawate, Yosuke Morita, Kenta Sasaki, Ryohei |
author_facet | Nakayama, Masao Akasaka, Hiroaki Miyazaki, Eiichi Goto, Yoshihiro Oki, Yuya Kawate, Yosuke Morita, Kenta Sasaki, Ryohei |
author_sort | Nakayama, Masao |
collection | PubMed |
description | Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes. |
format | Online Article Text |
id | pubmed-8626564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-86265642021-12-02 Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy Nakayama, Masao Akasaka, Hiroaki Miyazaki, Eiichi Goto, Yoshihiro Oki, Yuya Kawate, Yosuke Morita, Kenta Sasaki, Ryohei Phys Imaging Radiat Oncol Technical Note Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes. Elsevier 2021-11-23 /pmc/articles/PMC8626564/ /pubmed/34869923 http://dx.doi.org/10.1016/j.phro.2021.11.003 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Technical Note Nakayama, Masao Akasaka, Hiroaki Miyazaki, Eiichi Goto, Yoshihiro Oki, Yuya Kawate, Yosuke Morita, Kenta Sasaki, Ryohei Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy |
title | Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy |
title_full | Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy |
title_fullStr | Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy |
title_full_unstemmed | Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy |
title_short | Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy |
title_sort | image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy |
topic | Technical Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626564/ https://www.ncbi.nlm.nih.gov/pubmed/34869923 http://dx.doi.org/10.1016/j.phro.2021.11.003 |
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