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Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy

Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different conce...

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Autores principales: Nakayama, Masao, Akasaka, Hiroaki, Miyazaki, Eiichi, Goto, Yoshihiro, Oki, Yuya, Kawate, Yosuke, Morita, Kenta, Sasaki, Ryohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626564/
https://www.ncbi.nlm.nih.gov/pubmed/34869923
http://dx.doi.org/10.1016/j.phro.2021.11.003
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author Nakayama, Masao
Akasaka, Hiroaki
Miyazaki, Eiichi
Goto, Yoshihiro
Oki, Yuya
Kawate, Yosuke
Morita, Kenta
Sasaki, Ryohei
author_facet Nakayama, Masao
Akasaka, Hiroaki
Miyazaki, Eiichi
Goto, Yoshihiro
Oki, Yuya
Kawate, Yosuke
Morita, Kenta
Sasaki, Ryohei
author_sort Nakayama, Masao
collection PubMed
description Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes.
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spelling pubmed-86265642021-12-02 Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy Nakayama, Masao Akasaka, Hiroaki Miyazaki, Eiichi Goto, Yoshihiro Oki, Yuya Kawate, Yosuke Morita, Kenta Sasaki, Ryohei Phys Imaging Radiat Oncol Technical Note Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes. Elsevier 2021-11-23 /pmc/articles/PMC8626564/ /pubmed/34869923 http://dx.doi.org/10.1016/j.phro.2021.11.003 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Technical Note
Nakayama, Masao
Akasaka, Hiroaki
Miyazaki, Eiichi
Goto, Yoshihiro
Oki, Yuya
Kawate, Yosuke
Morita, Kenta
Sasaki, Ryohei
Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
title Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
title_full Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
title_fullStr Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
title_full_unstemmed Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
title_short Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
title_sort image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626564/
https://www.ncbi.nlm.nih.gov/pubmed/34869923
http://dx.doi.org/10.1016/j.phro.2021.11.003
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