The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy

Preserving optimal mitochondrial function is critical in the heart, which is the most ATP-avid organ in the body. Recently, we showed that global deficiency of the nuclear receptor RORα in the “staggerer” mouse exacerbates angiotensin II–induced cardiac hypertrophy and compromises cardiomyocyte mito...

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Detalles Bibliográficos
Autores principales: Beak, Ju Youn, Kang, Hong Soon, Huang, Wei, Deshmukh, Rishi, Hong, Seok Jae, Kadakia, Nishi, Aghajanian, Amir, Gerrish, Kevin, Jetten, Anton, Jensen, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626585/
https://www.ncbi.nlm.nih.gov/pubmed/34756888
http://dx.doi.org/10.1016/j.jbc.2021.101358

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