Microsecond simulations and CD spectroscopy reveals the intrinsically disordered nature of SARS-CoV-2 spike-C-terminal cytoplasmic tail (residues 1242–1273) in isolation

All available SARS-CoV-2 spike protein crystal and cryo-EM structures have shown missing electron densities for cytosolic C-terminal regions (CTR). Generally, the missing electron densities point towards the intrinsically disordered nature of the protein region (IDPR). This curiosity has led us to i...

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Detalles Bibliográficos
Autores principales: Kumar, Prateek, Bhardwaj, Taniya, Garg, Neha, Giri, Rajanish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626822/
https://www.ncbi.nlm.nih.gov/pubmed/34864296
http://dx.doi.org/10.1016/j.virol.2021.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626822/
https://www.ncbi.nlm.nih.gov/pubmed/34864296
http://dx.doi.org/10.1016/j.virol.2021.11.005

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