The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion

BACKGROUND: Type 3 von Willebrand disease (VWD) exhibits severe hemorrhagic tendency with complicated pathogenesis. The C-terminal cystine knot (CTCK) domain plays an important role in the dimerization and secretion of von Willebrand factor (VWF). The CTCK domain has four intrachain disulfide bonds...

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Detalles Bibliográficos
Autores principales: Zhang, Yuxin, Chen, Fengwu, Yang, Aizhen, Wang, Xiaoying, Han, Yue, Wu, Depei, Wu, Yi, Zhang, Jingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626975/
https://www.ncbi.nlm.nih.gov/pubmed/34838051
http://dx.doi.org/10.1186/s12959-021-00348-w

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