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Application of nanotechnology in the diagnosis and treatment of bladder cancer

Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need for mana...

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Autores principales: Xu, Yadong, Luo, Cheng, Wang, Jieqiong, Chen, Lingwu, Chen, Junxing, Chen, Tianfeng, Zeng, Qinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626998/
https://www.ncbi.nlm.nih.gov/pubmed/34838048
http://dx.doi.org/10.1186/s12951-021-01104-y
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author Xu, Yadong
Luo, Cheng
Wang, Jieqiong
Chen, Lingwu
Chen, Junxing
Chen, Tianfeng
Zeng, Qinsong
author_facet Xu, Yadong
Luo, Cheng
Wang, Jieqiong
Chen, Lingwu
Chen, Junxing
Chen, Tianfeng
Zeng, Qinsong
author_sort Xu, Yadong
collection PubMed
description Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need for management improvements in clinic. Nanotechnology has been proposed as an effective method to improve theranosis efficiency for both non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). For example, gold nanoparticles (AuNPs) have been developed for simple, fast and sensitive urinary sample test for bladder cancer diagnosis. Nanoparticles targeting bladder cancers can facilitate to distinguish the normal and abnormal bladder tissues during cystoscopy and thus help with the complete removal of malignant lesions. Both intravenous and intravesical agents can be modified by nanotechnology for targeted delivery, high anti-tumor efficiency and excellent tolerability, exhibiting encouraging potential in bladder cancer treatment. Photosensitizers and biological agents can also be delivered by nanotechnology, intermediating phototherapy and targeted therapy. The management of bladder cancer remained almost unchanged for decades with unsatisfactory effect. However, it is likely to change with the fast-developed nanotechnology. Herein we summarized the current utility of nanotechnology in bladder cancer diagnosis and treatment, providing insights for the future designing and discovering novel nanoparticles for bladder cancer management. [Image: see text]
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spelling pubmed-86269982021-11-30 Application of nanotechnology in the diagnosis and treatment of bladder cancer Xu, Yadong Luo, Cheng Wang, Jieqiong Chen, Lingwu Chen, Junxing Chen, Tianfeng Zeng, Qinsong J Nanobiotechnology Review Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high recurrence and progression rates after initial treatment indicate the urgent need for management improvements in clinic. Nanotechnology has been proposed as an effective method to improve theranosis efficiency for both non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). For example, gold nanoparticles (AuNPs) have been developed for simple, fast and sensitive urinary sample test for bladder cancer diagnosis. Nanoparticles targeting bladder cancers can facilitate to distinguish the normal and abnormal bladder tissues during cystoscopy and thus help with the complete removal of malignant lesions. Both intravenous and intravesical agents can be modified by nanotechnology for targeted delivery, high anti-tumor efficiency and excellent tolerability, exhibiting encouraging potential in bladder cancer treatment. Photosensitizers and biological agents can also be delivered by nanotechnology, intermediating phototherapy and targeted therapy. The management of bladder cancer remained almost unchanged for decades with unsatisfactory effect. However, it is likely to change with the fast-developed nanotechnology. Herein we summarized the current utility of nanotechnology in bladder cancer diagnosis and treatment, providing insights for the future designing and discovering novel nanoparticles for bladder cancer management. [Image: see text] BioMed Central 2021-11-27 /pmc/articles/PMC8626998/ /pubmed/34838048 http://dx.doi.org/10.1186/s12951-021-01104-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xu, Yadong
Luo, Cheng
Wang, Jieqiong
Chen, Lingwu
Chen, Junxing
Chen, Tianfeng
Zeng, Qinsong
Application of nanotechnology in the diagnosis and treatment of bladder cancer
title Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_full Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_fullStr Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_full_unstemmed Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_short Application of nanotechnology in the diagnosis and treatment of bladder cancer
title_sort application of nanotechnology in the diagnosis and treatment of bladder cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626998/
https://www.ncbi.nlm.nih.gov/pubmed/34838048
http://dx.doi.org/10.1186/s12951-021-01104-y
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