Cargando…

Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

BACKGROUND: Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study aimed to...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ruixue, Chen, Lifen, Liu, Yifeng, Wang, Feixia, Wang, Siwen, Huang, Yun, Hu, Kai-Lun, Fan, Yuzhi, Liu, Ruoyan, Zhang, Runjv, Zhang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627045/
https://www.ncbi.nlm.nih.gov/pubmed/34836492
http://dx.doi.org/10.1186/s12884-021-04261-y
_version_ 1784606777885589504
author Chen, Ruixue
Chen, Lifen
Liu, Yifeng
Wang, Feixia
Wang, Siwen
Huang, Yun
Hu, Kai-Lun
Fan, Yuzhi
Liu, Ruoyan
Zhang, Runjv
Zhang, Dan
author_facet Chen, Ruixue
Chen, Lifen
Liu, Yifeng
Wang, Feixia
Wang, Siwen
Huang, Yun
Hu, Kai-Lun
Fan, Yuzhi
Liu, Ruoyan
Zhang, Runjv
Zhang, Dan
author_sort Chen, Ruixue
collection PubMed
description BACKGROUND: Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study aimed to investigate the associations of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles. METHODS: We conducted a retrospective cohort study including 5741 couples in their first fresh IVF/ICSI cycles admitted to Women’s Hospital, School of Medicine, Zhejiang University from January 2013 to July 2016. The primary outcome was birth defects, which was classified according to the International Classification of Diseases, 10th Revision. Secondary outcomes included preterm delivery rate, infant gender, birth weight, small-for-gestational age (SGA) and large-for-gestational age (LGA). Multilevel regression analyses were used to assess the associations of parental prepregnancy BMI with neonatal outcomes and birth defect. RESULTS: In singletons, couples with prepregnancy BMI ≥25 kg/m(2) had higher odds of LGA than those with BMI < 25 kg/m(2). The birth defect rate was significantly higher when paternal prepregnancy BMI ≥25 kg/m(2) in IVF cycles (aOR 1.82, 95% CI 1.06–3.10) and maternal BMI ≥25 kg/m(2) in ICSI cycles (aOR 4.89, 95% CI 1.45–16.53). For subcategories of birth defects, only the odds of congenital malformations of musculoskeletal system was significantly increased in IVF offspring with paternal BMI ≥25 kg/m(2) (aOR 4.55, 95% CI 1.32–15.71). For twins, there was no significant difference among four groups, except for the lower birth weight of IVF female infants. CONCLUSIONS: Parental prepregnancy BMI ≥25 kg/m(2) is associated with higher incidence of LGA in IVF/ICSI singletons. Paternal prepregnancy BMI ≥25 kg/m(2) was likely to have higher risk of birth defect in IVF offspring than those with BMI < 25 kg/m(2), particularly in the musculoskeletal system. It is essential for overweight or obesity couples to lose weight before IVF/ICSI treatments. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-021-04261-y.
format Online
Article
Text
id pubmed-8627045
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-86270452021-11-30 Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study Chen, Ruixue Chen, Lifen Liu, Yifeng Wang, Feixia Wang, Siwen Huang, Yun Hu, Kai-Lun Fan, Yuzhi Liu, Ruoyan Zhang, Runjv Zhang, Dan BMC Pregnancy Childbirth Research BACKGROUND: Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study aimed to investigate the associations of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles. METHODS: We conducted a retrospective cohort study including 5741 couples in their first fresh IVF/ICSI cycles admitted to Women’s Hospital, School of Medicine, Zhejiang University from January 2013 to July 2016. The primary outcome was birth defects, which was classified according to the International Classification of Diseases, 10th Revision. Secondary outcomes included preterm delivery rate, infant gender, birth weight, small-for-gestational age (SGA) and large-for-gestational age (LGA). Multilevel regression analyses were used to assess the associations of parental prepregnancy BMI with neonatal outcomes and birth defect. RESULTS: In singletons, couples with prepregnancy BMI ≥25 kg/m(2) had higher odds of LGA than those with BMI < 25 kg/m(2). The birth defect rate was significantly higher when paternal prepregnancy BMI ≥25 kg/m(2) in IVF cycles (aOR 1.82, 95% CI 1.06–3.10) and maternal BMI ≥25 kg/m(2) in ICSI cycles (aOR 4.89, 95% CI 1.45–16.53). For subcategories of birth defects, only the odds of congenital malformations of musculoskeletal system was significantly increased in IVF offspring with paternal BMI ≥25 kg/m(2) (aOR 4.55, 95% CI 1.32–15.71). For twins, there was no significant difference among four groups, except for the lower birth weight of IVF female infants. CONCLUSIONS: Parental prepregnancy BMI ≥25 kg/m(2) is associated with higher incidence of LGA in IVF/ICSI singletons. Paternal prepregnancy BMI ≥25 kg/m(2) was likely to have higher risk of birth defect in IVF offspring than those with BMI < 25 kg/m(2), particularly in the musculoskeletal system. It is essential for overweight or obesity couples to lose weight before IVF/ICSI treatments. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-021-04261-y. BioMed Central 2021-11-27 /pmc/articles/PMC8627045/ /pubmed/34836492 http://dx.doi.org/10.1186/s12884-021-04261-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Ruixue
Chen, Lifen
Liu, Yifeng
Wang, Feixia
Wang, Siwen
Huang, Yun
Hu, Kai-Lun
Fan, Yuzhi
Liu, Ruoyan
Zhang, Runjv
Zhang, Dan
Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_full Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_fullStr Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_full_unstemmed Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_short Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
title_sort association of parental prepregnancy bmi with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627045/
https://www.ncbi.nlm.nih.gov/pubmed/34836492
http://dx.doi.org/10.1186/s12884-021-04261-y
work_keys_str_mv AT chenruixue associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT chenlifen associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT liuyifeng associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT wangfeixia associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT wangsiwen associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT huangyun associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT hukailun associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT fanyuzhi associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT liuruoyan associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT zhangrunjv associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy
AT zhangdan associationofparentalprepregnancybmiwithneonataloutcomesandbirthdefectinfreshembryotransfercyclesaretrospectivecohortstudy