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Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy
Drug-resistant tuberculosis (DR-TB) requires prolonged and complex therapy which is associated with several adverse drug reactions (ADR). The burden of ADR can affect the quality of life (QoL) of patients that consists of physical, mental, and social well-being, and influences the beliefs and behavi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627322/ https://www.ncbi.nlm.nih.gov/pubmed/34848950 http://dx.doi.org/10.2147/PPA.S333111 |
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author | Ausi, Yudisia Santoso, Prayudi Sunjaya, Deni Kurniadi Barliana, Melisa Intan |
author_facet | Ausi, Yudisia Santoso, Prayudi Sunjaya, Deni Kurniadi Barliana, Melisa Intan |
author_sort | Ausi, Yudisia |
collection | PubMed |
description | Drug-resistant tuberculosis (DR-TB) requires prolonged and complex therapy which is associated with several adverse drug reactions (ADR). The burden of ADR can affect the quality of life (QoL) of patients that consists of physical, mental, and social well-being, and influences the beliefs and behaviors of patient related to treatment. This article reviews the burden of ADR and its association with QoL and adherence. We used PubMed to retrieve the relevant original research articles written in English from 2011 to 2021. We combined the following keywords: “tuberculosis,” “Drug-resistant tuberculosis,” “Side Effect,” “Adverse Drug Reactions,” “Adverse Event,” “Quality of Life,” “Adherence,” “Non-adherence,” “Default,” and “Loss to follow-up.” Article selection process was unsystematic. We included 12 relevant main articles and summarized into two main topics, namely, 1) ADR and QoL (3 articles), and 2) ADR and therapy adherence (9 articles). The result showed that patients with ADR tend to have low QoL, even in the end of treatment. Although it was torturing, the presence of ADR does not always result in non-adherence. It is probably because the perception about the benefit of the treatment dominates the perceived barrier. In conclusion, burden of ADR generally tends to degrade QoL of patients and potentially influence the adherence. A comprehensive support from family, community, and healthcare provider is required to help patients in coping with the burden of ADR. Nevertheless, the regimen safety and efficacy improvement are highly needed. |
format | Online Article Text |
id | pubmed-8627322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-86273222021-11-29 Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy Ausi, Yudisia Santoso, Prayudi Sunjaya, Deni Kurniadi Barliana, Melisa Intan Patient Prefer Adherence Review Drug-resistant tuberculosis (DR-TB) requires prolonged and complex therapy which is associated with several adverse drug reactions (ADR). The burden of ADR can affect the quality of life (QoL) of patients that consists of physical, mental, and social well-being, and influences the beliefs and behaviors of patient related to treatment. This article reviews the burden of ADR and its association with QoL and adherence. We used PubMed to retrieve the relevant original research articles written in English from 2011 to 2021. We combined the following keywords: “tuberculosis,” “Drug-resistant tuberculosis,” “Side Effect,” “Adverse Drug Reactions,” “Adverse Event,” “Quality of Life,” “Adherence,” “Non-adherence,” “Default,” and “Loss to follow-up.” Article selection process was unsystematic. We included 12 relevant main articles and summarized into two main topics, namely, 1) ADR and QoL (3 articles), and 2) ADR and therapy adherence (9 articles). The result showed that patients with ADR tend to have low QoL, even in the end of treatment. Although it was torturing, the presence of ADR does not always result in non-adherence. It is probably because the perception about the benefit of the treatment dominates the perceived barrier. In conclusion, burden of ADR generally tends to degrade QoL of patients and potentially influence the adherence. A comprehensive support from family, community, and healthcare provider is required to help patients in coping with the burden of ADR. Nevertheless, the regimen safety and efficacy improvement are highly needed. Dove 2021-11-23 /pmc/articles/PMC8627322/ /pubmed/34848950 http://dx.doi.org/10.2147/PPA.S333111 Text en © 2021 Ausi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Ausi, Yudisia Santoso, Prayudi Sunjaya, Deni Kurniadi Barliana, Melisa Intan Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy |
title | Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy |
title_full | Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy |
title_fullStr | Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy |
title_full_unstemmed | Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy |
title_short | Between Curing and Torturing: Burden of Adverse Reaction in Drug-Resistant Tuberculosis Therapy |
title_sort | between curing and torturing: burden of adverse reaction in drug-resistant tuberculosis therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627322/ https://www.ncbi.nlm.nih.gov/pubmed/34848950 http://dx.doi.org/10.2147/PPA.S333111 |
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