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Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1

BACKGROUND: Natural killer (NK) cells require a functional lytic granule machinery to mediate effective antitumor responses. Evading the lytic cargo deployed at the immune synapse (IS) could be a critical step for cancer progression through yet unidentified mechanisms. METHODS: NK cell antibody-depe...

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Detalles Bibliográficos
Autores principales:	Darwich, Abbass, Silvestri, Alessandra, Benmebarek, Mohamed-Reda, Mouriès, Juliette, Cadilha, Bruno, Melacarne, Alessia, Morelli, Lapo, Supino, Domenico, Taleb, Alexandre, Obeck, Hannah, Sustmann, Claudio, Losurdo, Agnese, Masci, Giovanna, Curigliano, Giuseppe, Kobold, Sebastian, Penna, Giuseppe, Rescigno, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627417/ https://www.ncbi.nlm.nih.gov/pubmed/34824159 http://dx.doi.org/10.1136/jitc-2021-003224

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