Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy

BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy...

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Detalles Bibliográficos
Autores principales: Alvarez, Maite, Molina, Carmen, De Andrea, Carlos E, Fernandez-Sendin, Myriam, Villalba, Maria, Gonzalez-Gomariz, Jose, Ochoa, Maria Carmen, Teijeira, Alvaro, Glez-Vaz, Javier, Aranda, Fernando, Sanmamed, Miguel F, Rodriguez-Ruiz, Maria E, Fan, Xinyi, Shen, Wen H, Berraondo, Pedro, Quintero, Marisol, Melero, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627419/
https://www.ncbi.nlm.nih.gov/pubmed/34824158
http://dx.doi.org/10.1136/jitc-2021-002953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627419/
https://www.ncbi.nlm.nih.gov/pubmed/34824158
http://dx.doi.org/10.1136/jitc-2021-002953

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