Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test

A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ f...

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Detalles Bibliográficos
Autores principales: Yamaba, Yusuke, Takakuwa, Osamu, Ida, Chiaki, Saito, Manami, Kawae, Daisuke, Yoshihara, Misuzu, Kunii, Eiji, Imaeda, Kenro, Tatsuno, Ichiro, Hasegawa, Tadao, Akita, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627819/
https://www.ncbi.nlm.nih.gov/pubmed/33994434
http://dx.doi.org/10.2169/internalmedicine.6290-20
Descripción
Sumario:A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient.

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