Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test

A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ f...

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Autores principales: Yamaba, Yusuke, Takakuwa, Osamu, Ida, Chiaki, Saito, Manami, Kawae, Daisuke, Yoshihara, Misuzu, Kunii, Eiji, Imaeda, Kenro, Tatsuno, Ichiro, Hasegawa, Tadao, Akita, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627819/
https://www.ncbi.nlm.nih.gov/pubmed/33994434
http://dx.doi.org/10.2169/internalmedicine.6290-20
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author Yamaba, Yusuke
Takakuwa, Osamu
Ida, Chiaki
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Kunii, Eiji
Imaeda, Kenro
Tatsuno, Ichiro
Hasegawa, Tadao
Akita, Kenji
author_facet Yamaba, Yusuke
Takakuwa, Osamu
Ida, Chiaki
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Kunii, Eiji
Imaeda, Kenro
Tatsuno, Ichiro
Hasegawa, Tadao
Akita, Kenji
author_sort Yamaba, Yusuke
collection PubMed
description A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient.
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spelling pubmed-86278192021-12-10 Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test Yamaba, Yusuke Takakuwa, Osamu Ida, Chiaki Saito, Manami Kawae, Daisuke Yoshihara, Misuzu Kunii, Eiji Imaeda, Kenro Tatsuno, Ichiro Hasegawa, Tadao Akita, Kenji Intern Med Case Report A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient. The Japanese Society of Internal Medicine 2021-05-14 2021-11-01 /pmc/articles/PMC8627819/ /pubmed/33994434 http://dx.doi.org/10.2169/internalmedicine.6290-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamaba, Yusuke
Takakuwa, Osamu
Ida, Chiaki
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Kunii, Eiji
Imaeda, Kenro
Tatsuno, Ichiro
Hasegawa, Tadao
Akita, Kenji
Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test
title Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test
title_full Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test
title_fullStr Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test
title_full_unstemmed Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test
title_short Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test
title_sort streptococcal toxic shock syndrome induced by group a streptococcus with the emm28 genotype that developed after a uterine cancer test
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627819/
https://www.ncbi.nlm.nih.gov/pubmed/33994434
http://dx.doi.org/10.2169/internalmedicine.6290-20
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