Spontaneous Muscle Hematoma in Japanese Patients with Severe COVID-19 Treated with Unfractionated Heparin: Two Case Reports

In hospitalized coronavirus disease 2019 (COVID-19) patients, anticoagulation therapy is administered to prevent thrombosis. However, anticoagulation sometimes causes bleeding complications. We herein report two Japanese cases of severe COVID-19 in which spontaneous muscle hematomas (SMH) developed...

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Detalles Bibliográficos
Autores principales: Ito, Yu, Awano, Nobuyasu, Uchiyama, Fumiya, Inomata, Minoru, Kuse, Naoyuki, Tone, Mari, Takada, Kohei, Fujimoto, Kazushi, Muto, Yutaka, Sagisaka, Shogo, Maki, Kenro, Yamashita, Ryuta, Harada, Akinori, Nishimura, Jun-ichi, Hayashi, Munehiro, Izumo, Takehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627824/
https://www.ncbi.nlm.nih.gov/pubmed/34433713
http://dx.doi.org/10.2169/internalmedicine.7422-21
Descripción
Sumario:In hospitalized coronavirus disease 2019 (COVID-19) patients, anticoagulation therapy is administered to prevent thrombosis. However, anticoagulation sometimes causes bleeding complications. We herein report two Japanese cases of severe COVID-19 in which spontaneous muscle hematomas (SMH) developed under therapeutic anticoagulation with unfractionated heparin. Although the activated partial prothrombin time was within the optimal range, contrast-enhanced computed tomography (CECT) revealed SMH in the bilateral iliopsoas muscles in both cases, which required emergent transcatheter embolization. Close monitoring of the coagulation system and the early diagnosis of bleeding complications through CECT are needed in severe COVID-19 patients treated with anticoagulants.

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