The Role of IL-17 Cytokines in Psoriasis

Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation. The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically important role in the pathogenesis of psoriasis. The IL-17 effectors (IL-17A, IL-17C, IL-17E, and IL17F) act on keratinocyte...

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Autores principales: Mosca, Megan, Hong, Julie, Hadeler, Edward, Hakimi, Marwa, Liao, Wilson, Bhutani, Tina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627853/
https://www.ncbi.nlm.nih.gov/pubmed/34853779
http://dx.doi.org/10.2147/ITT.S240891
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author Mosca, Megan
Hong, Julie
Hadeler, Edward
Hakimi, Marwa
Liao, Wilson
Bhutani, Tina
author_facet Mosca, Megan
Hong, Julie
Hadeler, Edward
Hakimi, Marwa
Liao, Wilson
Bhutani, Tina
author_sort Mosca, Megan
collection PubMed
description Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation. The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically important role in the pathogenesis of psoriasis. The IL-17 effectors (IL-17A, IL-17C, IL-17E, and IL17F) act on keratinocytes, endothelial cells, and immune cells to stimulate epidermal hyperplasia and the pro-inflammatory feed-forward cycle seen within plaque psoriasis. The IL-17 pathway is also hypothesized to modulate the inflammatory responses linking comorbid systemic diseases with psoriasis. Furthermore, the robust clinical response seen with current and emerging therapies targeting IL-17 emphasizes the importance of the IL-17 cytokines in the pathogenesis of psoriasis.
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spelling pubmed-86278532021-11-30 The Role of IL-17 Cytokines in Psoriasis Mosca, Megan Hong, Julie Hadeler, Edward Hakimi, Marwa Liao, Wilson Bhutani, Tina Immunotargets Ther Review Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation. The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically important role in the pathogenesis of psoriasis. The IL-17 effectors (IL-17A, IL-17C, IL-17E, and IL17F) act on keratinocytes, endothelial cells, and immune cells to stimulate epidermal hyperplasia and the pro-inflammatory feed-forward cycle seen within plaque psoriasis. The IL-17 pathway is also hypothesized to modulate the inflammatory responses linking comorbid systemic diseases with psoriasis. Furthermore, the robust clinical response seen with current and emerging therapies targeting IL-17 emphasizes the importance of the IL-17 cytokines in the pathogenesis of psoriasis. Dove 2021-11-24 /pmc/articles/PMC8627853/ /pubmed/34853779 http://dx.doi.org/10.2147/ITT.S240891 Text en © 2021 Mosca et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Mosca, Megan
Hong, Julie
Hadeler, Edward
Hakimi, Marwa
Liao, Wilson
Bhutani, Tina
The Role of IL-17 Cytokines in Psoriasis
title The Role of IL-17 Cytokines in Psoriasis
title_full The Role of IL-17 Cytokines in Psoriasis
title_fullStr The Role of IL-17 Cytokines in Psoriasis
title_full_unstemmed The Role of IL-17 Cytokines in Psoriasis
title_short The Role of IL-17 Cytokines in Psoriasis
title_sort role of il-17 cytokines in psoriasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627853/
https://www.ncbi.nlm.nih.gov/pubmed/34853779
http://dx.doi.org/10.2147/ITT.S240891
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