Cargando…

The RNA N6-Methyladenosine Demethylase FTO Promotes Head and Neck Squamous Cell Carcinoma Proliferation and Migration by Increasing CTNNB1

OBJECTIVE: In this study, we aimed to investigate the role of RNA N6-methyladenosine demethylase fat mass and obesity-associated protein (FTO) in head and neck squamous cell carcinoma (HNSCC). METHODS: Clinical data downloaded from The Cancer Genome Atlas (TCGA) database were used to analyze the rel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yu, Chen, Lixiao, Wu, Xiaoliang, Sun, Zhenfeng, Wang, Fei, Wang, Baoxin, Dong, Pin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627861/ https://www.ncbi.nlm.nih.gov/pubmed/34853532 http://dx.doi.org/10.2147/IJGM.S339095

Ejemplares similares

m(6)A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte
por: Li, Kan, et al.
Publicado: (2022)

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

N(6)-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury
por: Xu, Kaiwei, et al.
Publicado: (2020)

N(6) ‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion
por: Wang, Wei, et al.
Publicado: (2022)

Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation
por: Kuschman, Hannah Petraitis, et al.
Publicado: (2023)

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
por: Niu, Yi, et al.
Publicado: (2019)

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
por: Zou, Shui, et al.
Publicado: (2016)

N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO‐PGC‐1α signalling axis
por: Zhuang, Changshui, et al.
Publicado: (2019)

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
por: Bartosovic, Marek, et al.
Publicado: (2017)

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N(6)-methyladenosine demethylase activity in cells
por: Cheong, Adeline, et al.
Publicado: (2018)

N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
por: Zou, Libin, et al.
Publicado: (2022)

A novel inhibitor of N(6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities
por: Xie, Guoyou, et al.
Publicado: (2022)

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers
por: Wang, Jin-yan, et al.
Publicado: (2020)

RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation
por: Wang, Jing, et al.
Publicado: (2021)

N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation
por: Du, Ying Dong, et al.
Publicado: (2021)

N(6)‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons
por: Li, Yize, et al.
Publicado: (2020)

N(6)-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1
por: Wang, Duo, et al.
Publicado: (2021)

Targeting the RNA demethylase FTO for cancer therapy
por: Zhou, Lin-Lin, et al.
Publicado: (2021)

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N (6)-methyladenosine demethylase FTO
por: Toh, Joel D. W., et al.
Publicado: (2015)

Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase
por: Marcinkowski, Michał, et al.
Publicado: (2021)

N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m(6)A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics
por: Zhou, You, et al.
Publicado: (2022)

RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m(6)A-YTHDF2-dependent manner
por: Tan, Zhen, et al.
Publicado: (2022)

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
por: Li, Yue, et al.
Publicado: (2019)

The biology of FTO: from nucleic acid demethylase to amino acid sensor
por: Gulati, Pawan, et al.
Publicado: (2013)

m6A demethylase FTO and osteoporosis: potential therapeutic interventions
por: Huang, Mei, et al.
Publicado: (2023)

Protein methyltransferases and demethylases dictate CD8+ T-cell exclusion in squamous cell carcinoma of the head and neck
por: Vougiouklakis, Theodore, et al.
Publicado: (2017)

Exosomes Derived from Adipose Mesenchymal Stem Cells Carrying miRNA-22-3p Promote Schwann Cells Proliferation and Migration through Downregulation of PTEN
por: Yang, Jianqiang, et al.
Publicado: (2022)

Extracranial non-vestibular head and neck schwannomas
por: Wang, Baoxin, et al.
Publicado: (2015)

Substrates of the m(6)A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
por: Sommerkamp, Pia
Publicado: (2022)

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice
por: Sachse, Gregor, et al.
Publicado: (2018)

Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer
por: Qin, Bo, et al.
Publicado: (2022)

N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway
por: Liu, Yuanyuan, et al.
Publicado: (2023)

RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma
por: Cui, Yuanbo, et al.
Publicado: (2021)

Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents
por: Huff, Sarah, et al.
Publicado: (2022)

Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome
por: Luo, Jiahui, et al.
Publicado: (2021)

Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells
por: Acuña Sanhueza, Gustavo A, et al.
Publicado: (2012)

HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma
por: Zhang, Hongbo, et al.
Publicado: (2022)

GJB4 promotes gastric cancer cell proliferation and migration via Wnt/CTNNB1 pathway
por: Liu, GuiYuan, et al.
Publicado: (2019)

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
por: Zhao, Xu, et al.
Publicado: (2014)

AlkB RNA demethylase homologues and N (6) ‐methyladenosine are involved in Potyvirus infection
por: Yue, Jianying, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_b24apd0ue5bgi1hk8bn4q13vc5