MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics data and developed a biocomputational platform to construct a mathematical model...

Descripción completa

Detalles Bibliográficos
Autores principales: Acón, ManSai, Geiß, Carsten, Torres-Calvo, Jorge, Bravo-Estupiñan, Diana, Oviedo, Guillermo, Arias-Arias, Jorge L., Rojas-Matey, Luis A., Edwin, Baez, Vásquez-Vargas, Gloriana, Oses-Vargas, Yendry, Guevara-Coto, José, Segura-Castillo, Andrés, Siles-Canales, Francisco, Quirós-Barrantes, Steve, Régnier-Vigouroux, Anne, Mendes, Pedro, Mora-Rodríguez, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627999/
https://www.ncbi.nlm.nih.gov/pubmed/34877484
http://dx.doi.org/10.1016/j.isci.2021.103407

Ejemplares similares

Ejemplares similares