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Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry

Acetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in h...

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Autores principales: Formiga, Francesc, Rubio-Rivas, Manuel, Mora-Luján, José María, Escudero, Samara Campos, Martinez, Rosa Fernandez Madera, Mendez-Bailón, Manuel, Campo, Pedro Durán-del, Pérez, Andrea Riaño, García-Sánchez, Francisco-Javier, Alcalá-Pedrajas, José Nicolás, Hernández, Sergio Arnedo, Milian, Almudena Hernández, Díez, Ana Latorre, Sánchez, Ricardo Gil, Boixeda, Ramon, Vicente, Julio, Cortes, Begoña, Pérez, Carmen Mella, Espartero, María Esther Guisado, Castro, José López, Suárez, Santiago Rodríguez, Varona, Jose F., Gomez-Huelgas, Ricardo, Ramos-Rincón, Jose Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628049/
https://www.ncbi.nlm.nih.gov/pubmed/34843073
http://dx.doi.org/10.1007/s11739-021-02870-1
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author Formiga, Francesc
Rubio-Rivas, Manuel
Mora-Luján, José María
Escudero, Samara Campos
Martinez, Rosa Fernandez Madera
Mendez-Bailón, Manuel
Campo, Pedro Durán-del
Pérez, Andrea Riaño
García-Sánchez, Francisco-Javier
Alcalá-Pedrajas, José Nicolás
Hernández, Sergio Arnedo
Milian, Almudena Hernández
Díez, Ana Latorre
Sánchez, Ricardo Gil
Boixeda, Ramon
Vicente, Julio
Cortes, Begoña
Pérez, Carmen Mella
Espartero, María Esther Guisado
Castro, José López
Suárez, Santiago Rodríguez
Varona, Jose F.
Gomez-Huelgas, Ricardo
Ramos-Rincón, Jose Manuel
author_facet Formiga, Francesc
Rubio-Rivas, Manuel
Mora-Luján, José María
Escudero, Samara Campos
Martinez, Rosa Fernandez Madera
Mendez-Bailón, Manuel
Campo, Pedro Durán-del
Pérez, Andrea Riaño
García-Sánchez, Francisco-Javier
Alcalá-Pedrajas, José Nicolás
Hernández, Sergio Arnedo
Milian, Almudena Hernández
Díez, Ana Latorre
Sánchez, Ricardo Gil
Boixeda, Ramon
Vicente, Julio
Cortes, Begoña
Pérez, Carmen Mella
Espartero, María Esther Guisado
Castro, José López
Suárez, Santiago Rodríguez
Varona, Jose F.
Gomez-Huelgas, Ricardo
Ramos-Rincón, Jose Manuel
author_sort Formiga, Francesc
collection PubMed
description Acetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in hospitalized COVID-19 patients. We realized an observational retrospective cohort study of 20,641 patients with COVID-19 pneumonia collected and followed-up from Mar 1st, 2020 to May 1st, 2021, from the nationwide Spanish SEMI-COVID-19 Registry. Propensity score matching (PSM) was performed to determine whether treatment with ASA affected outcomes in COVID-19 patients. On hospital admission, 3291 (15.9%) patients were receiving ASA. After PSM, 3291 patients exposed to ASA and 2885 not-exposed patients were analyzed. In-hospital mortality was higher in the ASA group (30.4 vs. 16.9%, p < 0.001) in the global sample. After PSM, no differences were found between groups (30.4 vs. 30.3%, p = 0.938). There were no differences in inflammation, symptomatic thrombosis, or ICU admission. In conclusion, ASA intake is not associated with in-hospital mortality or any other health outcome evaluated after applying PSM analysis in a real-world large sample of hospitalized COVID-19 patients.
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spelling pubmed-86280492021-11-29 Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry Formiga, Francesc Rubio-Rivas, Manuel Mora-Luján, José María Escudero, Samara Campos Martinez, Rosa Fernandez Madera Mendez-Bailón, Manuel Campo, Pedro Durán-del Pérez, Andrea Riaño García-Sánchez, Francisco-Javier Alcalá-Pedrajas, José Nicolás Hernández, Sergio Arnedo Milian, Almudena Hernández Díez, Ana Latorre Sánchez, Ricardo Gil Boixeda, Ramon Vicente, Julio Cortes, Begoña Pérez, Carmen Mella Espartero, María Esther Guisado Castro, José López Suárez, Santiago Rodríguez Varona, Jose F. Gomez-Huelgas, Ricardo Ramos-Rincón, Jose Manuel Intern Emerg Med Im - Original Acetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in hospitalized COVID-19 patients. We realized an observational retrospective cohort study of 20,641 patients with COVID-19 pneumonia collected and followed-up from Mar 1st, 2020 to May 1st, 2021, from the nationwide Spanish SEMI-COVID-19 Registry. Propensity score matching (PSM) was performed to determine whether treatment with ASA affected outcomes in COVID-19 patients. On hospital admission, 3291 (15.9%) patients were receiving ASA. After PSM, 3291 patients exposed to ASA and 2885 not-exposed patients were analyzed. In-hospital mortality was higher in the ASA group (30.4 vs. 16.9%, p < 0.001) in the global sample. After PSM, no differences were found between groups (30.4 vs. 30.3%, p = 0.938). There were no differences in inflammation, symptomatic thrombosis, or ICU admission. In conclusion, ASA intake is not associated with in-hospital mortality or any other health outcome evaluated after applying PSM analysis in a real-world large sample of hospitalized COVID-19 patients. Springer International Publishing 2021-11-29 2022 /pmc/articles/PMC8628049/ /pubmed/34843073 http://dx.doi.org/10.1007/s11739-021-02870-1 Text en © Società Italiana di Medicina Interna (SIMI) 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Im - Original
Formiga, Francesc
Rubio-Rivas, Manuel
Mora-Luján, José María
Escudero, Samara Campos
Martinez, Rosa Fernandez Madera
Mendez-Bailón, Manuel
Campo, Pedro Durán-del
Pérez, Andrea Riaño
García-Sánchez, Francisco-Javier
Alcalá-Pedrajas, José Nicolás
Hernández, Sergio Arnedo
Milian, Almudena Hernández
Díez, Ana Latorre
Sánchez, Ricardo Gil
Boixeda, Ramon
Vicente, Julio
Cortes, Begoña
Pérez, Carmen Mella
Espartero, María Esther Guisado
Castro, José López
Suárez, Santiago Rodríguez
Varona, Jose F.
Gomez-Huelgas, Ricardo
Ramos-Rincón, Jose Manuel
Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry
title Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry
title_full Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry
title_fullStr Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry
title_full_unstemmed Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry
title_short Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry
title_sort does admission acetylsalicylic acid uptake in hospitalized covid-19 patients have a protective role? data from the spanish semi-covid-19 registry
topic Im - Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628049/
https://www.ncbi.nlm.nih.gov/pubmed/34843073
http://dx.doi.org/10.1007/s11739-021-02870-1
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