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SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases
Coronavirus disease-2019 (COVID-19) is asymptomatic in most cases, but it is impartible and fatal in fragile and elderly people. Heretofore, more than four million people succumbed to COVID-19, while it spreads to every part of the globe. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628126/ https://www.ncbi.nlm.nih.gov/pubmed/34853527 http://dx.doi.org/10.2147/JIR.S332705 |
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author | Murugan, Avaniyapuram Kannan Alzahrani, Ali S |
author_facet | Murugan, Avaniyapuram Kannan Alzahrani, Ali S |
author_sort | Murugan, Avaniyapuram Kannan |
collection | PubMed |
description | Coronavirus disease-2019 (COVID-19) is asymptomatic in most cases, but it is impartible and fatal in fragile and elderly people. Heretofore, more than four million people succumbed to COVID-19, while it spreads to every part of the globe. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induces various dysfunctions in many vital organs including the thyroid by utilizing ACE2 as a receptor for cellular entry. Emerging reports clearly show the involvement of SARS-CoV-2 in diverse thyroid disorders. Thus, this review article aims to review comprehensively all the recent developments in SARS-CoV-2-induced pathogenesis of thyroid diseases. The review briefly summarizes the recent key findings on the mechanism of SARS-CoV-2 infection, the role of ACE2 receptor in viral entry, SARS-CoV-2-activated molecular signaling in host cells, ACE2 expression in the thyroid, cytokine storm, and its vital role in thyroid dysfunction and long-COVID in relation to thyroid and autoimmunity. Further, it extensively discusses rapidly evolving knowledge on the potential part of SARS-CoV-2 in emerging various thyroid dysfunctions during and post-COVID-19 conditions which include subacute thyroiditis, Graves' diseases, Hashimoto’s thyroiditis, thyrotoxicosis, and other recent advances in further discerning the implications of this virus within thyroid dysfunction. Unraveling the pathophysiology of SARS-CoV-2-triggered thyroid dysfunctions may aid pertinent therapeutic options and management of these patients in both during and post-COVID-19 scenarios. |
format | Online Article Text |
id | pubmed-8628126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-86281262021-11-30 SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases Murugan, Avaniyapuram Kannan Alzahrani, Ali S J Inflamm Res Review Coronavirus disease-2019 (COVID-19) is asymptomatic in most cases, but it is impartible and fatal in fragile and elderly people. Heretofore, more than four million people succumbed to COVID-19, while it spreads to every part of the globe. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induces various dysfunctions in many vital organs including the thyroid by utilizing ACE2 as a receptor for cellular entry. Emerging reports clearly show the involvement of SARS-CoV-2 in diverse thyroid disorders. Thus, this review article aims to review comprehensively all the recent developments in SARS-CoV-2-induced pathogenesis of thyroid diseases. The review briefly summarizes the recent key findings on the mechanism of SARS-CoV-2 infection, the role of ACE2 receptor in viral entry, SARS-CoV-2-activated molecular signaling in host cells, ACE2 expression in the thyroid, cytokine storm, and its vital role in thyroid dysfunction and long-COVID in relation to thyroid and autoimmunity. Further, it extensively discusses rapidly evolving knowledge on the potential part of SARS-CoV-2 in emerging various thyroid dysfunctions during and post-COVID-19 conditions which include subacute thyroiditis, Graves' diseases, Hashimoto’s thyroiditis, thyrotoxicosis, and other recent advances in further discerning the implications of this virus within thyroid dysfunction. Unraveling the pathophysiology of SARS-CoV-2-triggered thyroid dysfunctions may aid pertinent therapeutic options and management of these patients in both during and post-COVID-19 scenarios. Dove 2021-11-24 /pmc/articles/PMC8628126/ /pubmed/34853527 http://dx.doi.org/10.2147/JIR.S332705 Text en © 2021 Murugan and Alzahrani. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Murugan, Avaniyapuram Kannan Alzahrani, Ali S SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases |
title | SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases |
title_full | SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases |
title_fullStr | SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases |
title_full_unstemmed | SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases |
title_short | SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases |
title_sort | sars-cov-2: emerging role in the pathogenesis of various thyroid diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628126/ https://www.ncbi.nlm.nih.gov/pubmed/34853527 http://dx.doi.org/10.2147/JIR.S332705 |
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