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A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!

Sickle cell disease (SCD) is a group of hemoglobinopathies that vary in severity, the most severe form, homozygous sickle cell anemia, is more commonly associated with neurologic complications. These are attributed to the vaso-occlusion and micro-obstruction in the circulation of the central nervous...

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Autores principales: Kamath, Sangita D, Pai, Manish Ganesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628230/
https://www.ncbi.nlm.nih.gov/pubmed/34908763
http://dx.doi.org/10.4103/ajts.AJTS_101_18
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author Kamath, Sangita D
Pai, Manish Ganesh
author_facet Kamath, Sangita D
Pai, Manish Ganesh
author_sort Kamath, Sangita D
collection PubMed
description Sickle cell disease (SCD) is a group of hemoglobinopathies that vary in severity, the most severe form, homozygous sickle cell anemia, is more commonly associated with neurologic complications. These are attributed to the vaso-occlusion and micro-obstruction in the circulation of the central nervous system. The incidence of various neurologic complications in SCD ranges from 6% to 30% in various series. The commonly reported in literature include silent cerebral infarction (SCI), ischemic stroke, transient ischemic attacks (TIAs), headaches, seizures and neurocognitive impairment. However, hemorrhagic complications like subarachnoid hemorrhage (SAH), hemorrhagic stroke, extradural and subdural hematomas, especially in absence of trauma are rarely thought of. We report three uncommon spontaneous hemorrhagic manifestations of sickle cell anemia – one case of parenchymal (intracerebral) bleed who presented with acute onset of parkinsonism and two cases of extradural hematoma (EDH) of which one patient had recurrent EDH at the same site which is hitherto not reported in the literature.
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spelling pubmed-86282302021-12-13 A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem! Kamath, Sangita D Pai, Manish Ganesh Asian J Transfus Sci Case Report Sickle cell disease (SCD) is a group of hemoglobinopathies that vary in severity, the most severe form, homozygous sickle cell anemia, is more commonly associated with neurologic complications. These are attributed to the vaso-occlusion and micro-obstruction in the circulation of the central nervous system. The incidence of various neurologic complications in SCD ranges from 6% to 30% in various series. The commonly reported in literature include silent cerebral infarction (SCI), ischemic stroke, transient ischemic attacks (TIAs), headaches, seizures and neurocognitive impairment. However, hemorrhagic complications like subarachnoid hemorrhage (SAH), hemorrhagic stroke, extradural and subdural hematomas, especially in absence of trauma are rarely thought of. We report three uncommon spontaneous hemorrhagic manifestations of sickle cell anemia – one case of parenchymal (intracerebral) bleed who presented with acute onset of parkinsonism and two cases of extradural hematoma (EDH) of which one patient had recurrent EDH at the same site which is hitherto not reported in the literature. Wolters Kluwer - Medknow 2021 2021-11-01 /pmc/articles/PMC8628230/ /pubmed/34908763 http://dx.doi.org/10.4103/ajts.AJTS_101_18 Text en Copyright: © 2021 Asian Journal of Transfusion Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Kamath, Sangita D
Pai, Manish Ganesh
A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_full A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_fullStr A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_full_unstemmed A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_short A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
title_sort case series of hemorrhagic neurological complications of sickle cell disease: multiple faces of an underestimated problem!
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628230/
https://www.ncbi.nlm.nih.gov/pubmed/34908763
http://dx.doi.org/10.4103/ajts.AJTS_101_18
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