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Analysis of red blood cell irradiation practices from South India

INTRODUCTION: Age of red blood cell (RBC) units at the time of irradiation is important and prolonged storage of preirradiated units is detrimental. The objectives were to determine RBC age at irradiation, days from expiry (DFE), and percentage of late transfusions of irradiated RBC. To estimate the...

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Autores principales: Murugesan, Mohandoss, Augustine, Merline, Nayanar, Sangeetha Keloth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628245/
https://www.ncbi.nlm.nih.gov/pubmed/34908755
http://dx.doi.org/10.4103/ajts.ajts_60_21
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author Murugesan, Mohandoss
Augustine, Merline
Nayanar, Sangeetha Keloth
author_facet Murugesan, Mohandoss
Augustine, Merline
Nayanar, Sangeetha Keloth
author_sort Murugesan, Mohandoss
collection PubMed
description INTRODUCTION: Age of red blood cell (RBC) units at the time of irradiation is important and prolonged storage of preirradiated units is detrimental. The objectives were to determine RBC age at irradiation, days from expiry (DFE), and percentage of late transfusions of irradiated RBC. To estimate the concordance on expiry of irradiated RBC units with present American Association of Blood Banks (AABB)/Directorate General of Health Services (DGHS), New Delhi over British Committee for Standards in Hematology (BCSH) and Council of Europe (CE) guidelines. METHODS: All the RBC units irradiated for a 1 year period were included. Retrieved data included date of collection, irradiation, revised expiry, and issue of blood. Late transfusions are units transfused in the last 2 week of RBC's shelf-life and wastage due to expiry was determined. Chi-square and Kruskal–Wallis test were used for comparisons between the guidelines. RESULTS: Out of 1303 RBC units irradiated, the median age for irradiation was 2 (0–36) days and 99.3% units irradiated within day +14. Median DFE for these units transfused was 26 (0–28) days. 2.8% units expired as per local standards. Late transfusions happened in 121 (9.3%) units transfused. AABB/DGHS practice was not concordant with CE standards for 86 (6.6%) units and with BCSH 94 (7.2%) units. Overall discordance between the present practices was CE and BCSH was seen in 130 (10%) events. CONCLUSION: Median RBC irradiation age and DFE was two and 26 days respectively at our center. Only 90% concordance was observed between AABB/DGHS and CE/BCSH guidelines with 9.3% units transfused as late transfusions. Restricting late transfusions of irradiated RBC can act as surrogate to improve the quality of units transfused through an inexpensive strategy.
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spelling pubmed-86282452021-12-13 Analysis of red blood cell irradiation practices from South India Murugesan, Mohandoss Augustine, Merline Nayanar, Sangeetha Keloth Asian J Transfus Sci Original Article INTRODUCTION: Age of red blood cell (RBC) units at the time of irradiation is important and prolonged storage of preirradiated units is detrimental. The objectives were to determine RBC age at irradiation, days from expiry (DFE), and percentage of late transfusions of irradiated RBC. To estimate the concordance on expiry of irradiated RBC units with present American Association of Blood Banks (AABB)/Directorate General of Health Services (DGHS), New Delhi over British Committee for Standards in Hematology (BCSH) and Council of Europe (CE) guidelines. METHODS: All the RBC units irradiated for a 1 year period were included. Retrieved data included date of collection, irradiation, revised expiry, and issue of blood. Late transfusions are units transfused in the last 2 week of RBC's shelf-life and wastage due to expiry was determined. Chi-square and Kruskal–Wallis test were used for comparisons between the guidelines. RESULTS: Out of 1303 RBC units irradiated, the median age for irradiation was 2 (0–36) days and 99.3% units irradiated within day +14. Median DFE for these units transfused was 26 (0–28) days. 2.8% units expired as per local standards. Late transfusions happened in 121 (9.3%) units transfused. AABB/DGHS practice was not concordant with CE standards for 86 (6.6%) units and with BCSH 94 (7.2%) units. Overall discordance between the present practices was CE and BCSH was seen in 130 (10%) events. CONCLUSION: Median RBC irradiation age and DFE was two and 26 days respectively at our center. Only 90% concordance was observed between AABB/DGHS and CE/BCSH guidelines with 9.3% units transfused as late transfusions. Restricting late transfusions of irradiated RBC can act as surrogate to improve the quality of units transfused through an inexpensive strategy. Wolters Kluwer - Medknow 2021 2021-11-01 /pmc/articles/PMC8628245/ /pubmed/34908755 http://dx.doi.org/10.4103/ajts.ajts_60_21 Text en Copyright: © 2021 Asian Journal of Transfusion Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Murugesan, Mohandoss
Augustine, Merline
Nayanar, Sangeetha Keloth
Analysis of red blood cell irradiation practices from South India
title Analysis of red blood cell irradiation practices from South India
title_full Analysis of red blood cell irradiation practices from South India
title_fullStr Analysis of red blood cell irradiation practices from South India
title_full_unstemmed Analysis of red blood cell irradiation practices from South India
title_short Analysis of red blood cell irradiation practices from South India
title_sort analysis of red blood cell irradiation practices from south india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628245/
https://www.ncbi.nlm.nih.gov/pubmed/34908755
http://dx.doi.org/10.4103/ajts.ajts_60_21
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