WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway

Targeted therapies represent attractive combination partners with immune checkpoint blockade (ICB) to increase the population of patients who benefit or to interdict the emergence of resistance. We demonstrate that targeting WEE1 up-regulates immune signaling through the double-stranded RNA (dsRNA)...

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Detalles Bibliográficos
Autores principales: Guo, Ensong, Xiao, Rourou, Wu, Yifan, Lu, Funian, Liu, Chen, Yang, Bin, Li, Xi, Fu, Yu, Wang, Zizhuo, Li, Yuan, Huang, Yuhan, Li, Fuxia, Wu, Xue, You, Lixin, Qin, Tianyu, Lu, Yiling, Huang, Xiaoyuan, Ma, Ding, Mills, Gordon B., Sun, Chaoyang, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628262/
https://www.ncbi.nlm.nih.gov/pubmed/34825915
http://dx.doi.org/10.1084/jem.20210789

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