Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report

BACKGROUND: Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy. CASE PRESENTATION: We present a case of a 61-year-old Chinese man with severe...

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Detalles Bibliográficos
Autores principales: Li, Huiping, Yuan, Fang, Du, Yaming, Pan, Tao, Wen, Wanxin, Li, Shaoxue, Wang, Lixin, Lu, Aili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628425/
https://www.ncbi.nlm.nih.gov/pubmed/34844635
http://dx.doi.org/10.1186/s13256-021-03139-z
Descripción
Sumario:BACKGROUND: Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy. CASE PRESENTATION: We present a case of a 61-year-old Chinese man with severe progressive supranuclear palsy and treated with umbilical cord blood stem cells transplantation. After the umbilical cord blood stem cells therapy, his neurologic symptoms stopped deteriorating, his muscle rigidity was mildly improved, and he remains alive for more than 8 years. CONCLUSIONS: Umbilical cord blood stem cells transplantation may be an alternative therapy for patients with severe progressive supranuclear palsy.

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