Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report

BACKGROUND: Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy. CASE PRESENTATION: We present a case of a 61-year-old Chinese man with severe...

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Autores principales: Li, Huiping, Yuan, Fang, Du, Yaming, Pan, Tao, Wen, Wanxin, Li, Shaoxue, Wang, Lixin, Lu, Aili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628425/
https://www.ncbi.nlm.nih.gov/pubmed/34844635
http://dx.doi.org/10.1186/s13256-021-03139-z
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author Li, Huiping
Yuan, Fang
Du, Yaming
Pan, Tao
Wen, Wanxin
Li, Shaoxue
Wang, Lixin
Lu, Aili
author_facet Li, Huiping
Yuan, Fang
Du, Yaming
Pan, Tao
Wen, Wanxin
Li, Shaoxue
Wang, Lixin
Lu, Aili
author_sort Li, Huiping
collection PubMed
description BACKGROUND: Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy. CASE PRESENTATION: We present a case of a 61-year-old Chinese man with severe progressive supranuclear palsy and treated with umbilical cord blood stem cells transplantation. After the umbilical cord blood stem cells therapy, his neurologic symptoms stopped deteriorating, his muscle rigidity was mildly improved, and he remains alive for more than 8 years. CONCLUSIONS: Umbilical cord blood stem cells transplantation may be an alternative therapy for patients with severe progressive supranuclear palsy.
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spelling pubmed-86284252021-12-01 Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report Li, Huiping Yuan, Fang Du, Yaming Pan, Tao Wen, Wanxin Li, Shaoxue Wang, Lixin Lu, Aili J Med Case Rep Case Report BACKGROUND: Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy. CASE PRESENTATION: We present a case of a 61-year-old Chinese man with severe progressive supranuclear palsy and treated with umbilical cord blood stem cells transplantation. After the umbilical cord blood stem cells therapy, his neurologic symptoms stopped deteriorating, his muscle rigidity was mildly improved, and he remains alive for more than 8 years. CONCLUSIONS: Umbilical cord blood stem cells transplantation may be an alternative therapy for patients with severe progressive supranuclear palsy. BioMed Central 2021-11-29 /pmc/articles/PMC8628425/ /pubmed/34844635 http://dx.doi.org/10.1186/s13256-021-03139-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Li, Huiping
Yuan, Fang
Du, Yaming
Pan, Tao
Wen, Wanxin
Li, Shaoxue
Wang, Lixin
Lu, Aili
Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
title Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
title_full Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
title_fullStr Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
title_full_unstemmed Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
title_short Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
title_sort umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628425/
https://www.ncbi.nlm.nih.gov/pubmed/34844635
http://dx.doi.org/10.1186/s13256-021-03139-z
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