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Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying
In this work, the effect of two processes, i.e., freeze-drying and supercritical CO(2) (SC-CO(2)) drying, on the final morphology of agarose-based porous structures, was investigated. The agarose concentration in water was varied from 1 wt% up to 8 wt%. Agarose cryogels were prepared by freeze-dryin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628673/ https://www.ncbi.nlm.nih.gov/pubmed/34842697 http://dx.doi.org/10.3390/gels7040198 |
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author | Guastaferro, Mariangela Baldino, Lucia Reverchon, Ernesto Cardea, Stefano |
author_facet | Guastaferro, Mariangela Baldino, Lucia Reverchon, Ernesto Cardea, Stefano |
author_sort | Guastaferro, Mariangela |
collection | PubMed |
description | In this work, the effect of two processes, i.e., freeze-drying and supercritical CO(2) (SC-CO(2)) drying, on the final morphology of agarose-based porous structures, was investigated. The agarose concentration in water was varied from 1 wt% up to 8 wt%. Agarose cryogels were prepared by freeze-drying using two cooling rates: 2.5 °C/min and 0.1 °C/min. A more uniform macroporous structure and a decrease in average pore size were achieved when a fast cooling rate was adopted. When a slower cooling rate was performed instead, cryogels were characterized by a macroporous and heterogenous structure at all of the values of the biopolymer concentration investigated. SC-CO(2) drying led to the production of aerogels characterized by a mesoporous structure, with a specific surface area up to 170 m(2)/g. Moreover, agarose-based aerogels were solvent-free, and no thermal changes were detected in the samples after processing. |
format | Online Article Text |
id | pubmed-8628673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86286732021-11-30 Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying Guastaferro, Mariangela Baldino, Lucia Reverchon, Ernesto Cardea, Stefano Gels Article In this work, the effect of two processes, i.e., freeze-drying and supercritical CO(2) (SC-CO(2)) drying, on the final morphology of agarose-based porous structures, was investigated. The agarose concentration in water was varied from 1 wt% up to 8 wt%. Agarose cryogels were prepared by freeze-drying using two cooling rates: 2.5 °C/min and 0.1 °C/min. A more uniform macroporous structure and a decrease in average pore size were achieved when a fast cooling rate was adopted. When a slower cooling rate was performed instead, cryogels were characterized by a macroporous and heterogenous structure at all of the values of the biopolymer concentration investigated. SC-CO(2) drying led to the production of aerogels characterized by a mesoporous structure, with a specific surface area up to 170 m(2)/g. Moreover, agarose-based aerogels were solvent-free, and no thermal changes were detected in the samples after processing. MDPI 2021-11-05 /pmc/articles/PMC8628673/ /pubmed/34842697 http://dx.doi.org/10.3390/gels7040198 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guastaferro, Mariangela Baldino, Lucia Reverchon, Ernesto Cardea, Stefano Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying |
title | Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying |
title_full | Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying |
title_fullStr | Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying |
title_full_unstemmed | Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying |
title_short | Production of Porous Agarose-Based Structures: Freeze-Drying vs. Supercritical CO(2) Drying |
title_sort | production of porous agarose-based structures: freeze-drying vs. supercritical co(2) drying |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628673/ https://www.ncbi.nlm.nih.gov/pubmed/34842697 http://dx.doi.org/10.3390/gels7040198 |
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