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Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?

(1) Background: Anaemia is a common finding in patients with colon cancer and is commonly corrected by blood transfusion prior to surgery. However, the prognostic role of perioperative transfusions is still debated. The aim of the present study was to investigate the role of preoperative anaemia and...

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Autores principales: Tamini, Nicolò, Gianotti, Luca, Darwish, Shadya, Petitto, Salvatore, Bernasconi, Davide, Oldani, Massimo, Uggeri, Fabio, Braga, Marco, Nespoli, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628678/
https://www.ncbi.nlm.nih.gov/pubmed/34898556
http://dx.doi.org/10.3390/curroncol28060391
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author Tamini, Nicolò
Gianotti, Luca
Darwish, Shadya
Petitto, Salvatore
Bernasconi, Davide
Oldani, Massimo
Uggeri, Fabio
Braga, Marco
Nespoli, Luca
author_facet Tamini, Nicolò
Gianotti, Luca
Darwish, Shadya
Petitto, Salvatore
Bernasconi, Davide
Oldani, Massimo
Uggeri, Fabio
Braga, Marco
Nespoli, Luca
author_sort Tamini, Nicolò
collection PubMed
description (1) Background: Anaemia is a common finding in patients with colon cancer and is commonly corrected by blood transfusion prior to surgery. However, the prognostic role of perioperative transfusions is still debated. The aim of the present study was to investigate the role of preoperative anaemia and preoperative blood transfusion in influencing the prognosis in colon cancer. (2) Patients and Methods: Patients undergoing elective surgery for colon cancer at a tertiary referral university hospital between January 2010 and December 2018 were included in a retrospective review of a prospectively collected database. Univariate and regression analyses were performed to identify the prognostic role of preoperative anaemia and preoperative transfusions in this homogeneous cohort of patients. (3) Results: A total of 780 patients were included in the final analysis. The estimated five-year overall survival rate was significantly worse in the anaemic group (83.8% in non-anaemic patients, 60.6% in mild anaemic patients, 61.3% in moderate anaemic patients and 58.4% in severe anaemic patients; log-rank < 0.001 vs. non-anaemic patients). Anaemic status was found to be an independent adverse prognostic factor (hazard ratio (HR): 1.46; 95% confidence interval (CI): 1.02–2.07) during multivariate analysis. Among moderate to severe anaemic patients, no significant association was found between preoperative transfusions and the risk of mortality or recurrence. (4) Conclusions: Preoperative anaemia, regardless of its severity, and not preoperative blood transfusion, was independently associated with a worse prognosis after surgery in patients with colonic cancer.
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spelling pubmed-86286782021-11-30 Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer? Tamini, Nicolò Gianotti, Luca Darwish, Shadya Petitto, Salvatore Bernasconi, Davide Oldani, Massimo Uggeri, Fabio Braga, Marco Nespoli, Luca Curr Oncol Article (1) Background: Anaemia is a common finding in patients with colon cancer and is commonly corrected by blood transfusion prior to surgery. However, the prognostic role of perioperative transfusions is still debated. The aim of the present study was to investigate the role of preoperative anaemia and preoperative blood transfusion in influencing the prognosis in colon cancer. (2) Patients and Methods: Patients undergoing elective surgery for colon cancer at a tertiary referral university hospital between January 2010 and December 2018 were included in a retrospective review of a prospectively collected database. Univariate and regression analyses were performed to identify the prognostic role of preoperative anaemia and preoperative transfusions in this homogeneous cohort of patients. (3) Results: A total of 780 patients were included in the final analysis. The estimated five-year overall survival rate was significantly worse in the anaemic group (83.8% in non-anaemic patients, 60.6% in mild anaemic patients, 61.3% in moderate anaemic patients and 58.4% in severe anaemic patients; log-rank < 0.001 vs. non-anaemic patients). Anaemic status was found to be an independent adverse prognostic factor (hazard ratio (HR): 1.46; 95% confidence interval (CI): 1.02–2.07) during multivariate analysis. Among moderate to severe anaemic patients, no significant association was found between preoperative transfusions and the risk of mortality or recurrence. (4) Conclusions: Preoperative anaemia, regardless of its severity, and not preoperative blood transfusion, was independently associated with a worse prognosis after surgery in patients with colonic cancer. MDPI 2021-11-12 /pmc/articles/PMC8628678/ /pubmed/34898556 http://dx.doi.org/10.3390/curroncol28060391 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tamini, Nicolò
Gianotti, Luca
Darwish, Shadya
Petitto, Salvatore
Bernasconi, Davide
Oldani, Massimo
Uggeri, Fabio
Braga, Marco
Nespoli, Luca
Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?
title Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?
title_full Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?
title_fullStr Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?
title_full_unstemmed Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?
title_short Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?
title_sort do preoperative transfusions impact prognosis in moderate to severe anaemic surgical patients with colon cancer?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628678/
https://www.ncbi.nlm.nih.gov/pubmed/34898556
http://dx.doi.org/10.3390/curroncol28060391
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