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Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance

Using polyvinyl alcohol (PVA) and nanocellulose (NC) as raw materials, PVA/NC nanofiber membranes were prepared by electrospinning. The hydrogen bonding, crystalline properties and microscopic appearance of PVA/NC membranes with different NC contents were characterized. The mechanical properties, li...

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Autores principales: Ji, Xinbin, Guo, Jing, Guan, Fucheng, Liu, Yuanfa, Yang, Qiang, Zhang, Xin, Xu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628797/
https://www.ncbi.nlm.nih.gov/pubmed/34842695
http://dx.doi.org/10.3390/gels7040223
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author Ji, Xinbin
Guo, Jing
Guan, Fucheng
Liu, Yuanfa
Yang, Qiang
Zhang, Xin
Xu, Yi
author_facet Ji, Xinbin
Guo, Jing
Guan, Fucheng
Liu, Yuanfa
Yang, Qiang
Zhang, Xin
Xu, Yi
author_sort Ji, Xinbin
collection PubMed
description Using polyvinyl alcohol (PVA) and nanocellulose (NC) as raw materials, PVA/NC nanofiber membranes were prepared by electrospinning. The hydrogen bonding, crystalline properties and microscopic appearance of PVA/NC membranes with different NC contents were characterized. The mechanical properties, liquid absorption and cytotoxicity of the nanofiber membrane were evaluated. The results show that the free hydroxyl group of the PVA/NC nanofiber membranes have a maximum value of 9% at a mass fraction of 6% NC. The crystallinity of the PVA/NC nanofiber membranes and the average diameter of the nanofibers decreased and then increased as the NC content increased, with a minimum value of 38.23% and 272.03 nm, respectively, at 6% NC content. At this time, the contact angle was the smallest. The maximum strength of the PVA/NC nanofiber membranes is 75.8% higher than that of the PVA membrane at 2% NC content. With increasing NC content, the absorption of water, PBS sustained-release suspensions and artificial blood by PVA/NC nanofiber membranes increases. Cytotoxicity tests have shown that PVA/NC nanofiber membranes are non-toxic, have good cytocompatibility and are expected to be used in the field of medical dressings.
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spelling pubmed-86287972021-11-30 Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance Ji, Xinbin Guo, Jing Guan, Fucheng Liu, Yuanfa Yang, Qiang Zhang, Xin Xu, Yi Gels Article Using polyvinyl alcohol (PVA) and nanocellulose (NC) as raw materials, PVA/NC nanofiber membranes were prepared by electrospinning. The hydrogen bonding, crystalline properties and microscopic appearance of PVA/NC membranes with different NC contents were characterized. The mechanical properties, liquid absorption and cytotoxicity of the nanofiber membrane were evaluated. The results show that the free hydroxyl group of the PVA/NC nanofiber membranes have a maximum value of 9% at a mass fraction of 6% NC. The crystallinity of the PVA/NC nanofiber membranes and the average diameter of the nanofibers decreased and then increased as the NC content increased, with a minimum value of 38.23% and 272.03 nm, respectively, at 6% NC content. At this time, the contact angle was the smallest. The maximum strength of the PVA/NC nanofiber membranes is 75.8% higher than that of the PVA membrane at 2% NC content. With increasing NC content, the absorption of water, PBS sustained-release suspensions and artificial blood by PVA/NC nanofiber membranes increases. Cytotoxicity tests have shown that PVA/NC nanofiber membranes are non-toxic, have good cytocompatibility and are expected to be used in the field of medical dressings. MDPI 2021-11-19 /pmc/articles/PMC8628797/ /pubmed/34842695 http://dx.doi.org/10.3390/gels7040223 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ji, Xinbin
Guo, Jing
Guan, Fucheng
Liu, Yuanfa
Yang, Qiang
Zhang, Xin
Xu, Yi
Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance
title Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance
title_full Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance
title_fullStr Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance
title_full_unstemmed Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance
title_short Preparation of Electrospun Polyvinyl Alcohol/Nanocellulose Composite Film and Evaluation of Its Biomedical Performance
title_sort preparation of electrospun polyvinyl alcohol/nanocellulose composite film and evaluation of its biomedical performance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628797/
https://www.ncbi.nlm.nih.gov/pubmed/34842695
http://dx.doi.org/10.3390/gels7040223
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