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New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

In the last years, physical hydrogels have been widely studied due to the characteristics of these structures, respectively the non-covalent interactions and the absence of other necessary components for the cross-linking processes. Low molecular weight gelators are a class of small molecules which...

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Autores principales: Croitoriu, Alexandra, Nita, Loredana E., Chiriac, Aurica P., Rusu, Alina G., Bercea, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628802/
https://www.ncbi.nlm.nih.gov/pubmed/34842687
http://dx.doi.org/10.3390/gels7040208
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author Croitoriu, Alexandra
Nita, Loredana E.
Chiriac, Aurica P.
Rusu, Alina G.
Bercea, Maria
author_facet Croitoriu, Alexandra
Nita, Loredana E.
Chiriac, Aurica P.
Rusu, Alina G.
Bercea, Maria
author_sort Croitoriu, Alexandra
collection PubMed
description In the last years, physical hydrogels have been widely studied due to the characteristics of these structures, respectively the non-covalent interactions and the absence of other necessary components for the cross-linking processes. Low molecular weight gelators are a class of small molecules which form higher ordered structures through hydrogen bonding and π–π interactions. In this context it is known that the formation of hydrogels based on FMOC–amino acids is determined by the primary structures of amino acids and the secondary structure arrangement (alpha–helix or beta–sheet motifs). The present study aimed to obtain supramolecular gels through co-assembly phenomenon using FMOC–amino acids as low molecular weight gelators. The stability of the new structures was evaluated by the vial inversion test, while FTIR spectra put into evidence the interaction between the compounds. The gel-like structure is evidenced by viscoelastic parameters in oscillatory shear conditions. SEM microscopy was used to obtain the visual insight into the morphology of the physical hydrogel network while DLS measurements highlighted the sol-gel transition. The molecular arrangement of gels was determined by circular dichroism, fluorescence and UV-Vis spectroscopy.
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spelling pubmed-86288022021-11-30 New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids Croitoriu, Alexandra Nita, Loredana E. Chiriac, Aurica P. Rusu, Alina G. Bercea, Maria Gels Article In the last years, physical hydrogels have been widely studied due to the characteristics of these structures, respectively the non-covalent interactions and the absence of other necessary components for the cross-linking processes. Low molecular weight gelators are a class of small molecules which form higher ordered structures through hydrogen bonding and π–π interactions. In this context it is known that the formation of hydrogels based on FMOC–amino acids is determined by the primary structures of amino acids and the secondary structure arrangement (alpha–helix or beta–sheet motifs). The present study aimed to obtain supramolecular gels through co-assembly phenomenon using FMOC–amino acids as low molecular weight gelators. The stability of the new structures was evaluated by the vial inversion test, while FTIR spectra put into evidence the interaction between the compounds. The gel-like structure is evidenced by viscoelastic parameters in oscillatory shear conditions. SEM microscopy was used to obtain the visual insight into the morphology of the physical hydrogel network while DLS measurements highlighted the sol-gel transition. The molecular arrangement of gels was determined by circular dichroism, fluorescence and UV-Vis spectroscopy. MDPI 2021-11-12 /pmc/articles/PMC8628802/ /pubmed/34842687 http://dx.doi.org/10.3390/gels7040208 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Croitoriu, Alexandra
Nita, Loredana E.
Chiriac, Aurica P.
Rusu, Alina G.
Bercea, Maria
New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids
title New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids
title_full New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids
title_fullStr New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids
title_full_unstemmed New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids
title_short New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids
title_sort new physical hydrogels based on co-assembling of fmoc–amino acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628802/
https://www.ncbi.nlm.nih.gov/pubmed/34842687
http://dx.doi.org/10.3390/gels7040208
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