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Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF
Telomeres promote genome integrity by protecting chromosome ends from the activation of the DNA damage response and protecting chromosomes from the loss of coding sequences due to the end replication problem. Telomere length (TL) is progressively shortened as age progresses, thus resulting in cellul...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628962/ https://www.ncbi.nlm.nih.gov/pubmed/34842724 http://dx.doi.org/10.3390/jdb9040049 |
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author | Anifandis, George Samara, Maria Simopoulou, Mara Messini, Christina I. Chatzimeletiou, Katerina Thodou, Eleni Daponte, Alexandros Georgiou, Ioannis |
author_facet | Anifandis, George Samara, Maria Simopoulou, Mara Messini, Christina I. Chatzimeletiou, Katerina Thodou, Eleni Daponte, Alexandros Georgiou, Ioannis |
author_sort | Anifandis, George |
collection | PubMed |
description | Telomeres promote genome integrity by protecting chromosome ends from the activation of the DNA damage response and protecting chromosomes from the loss of coding sequences due to the end replication problem. Telomere length (TL) is progressively shortened as age progresses, thus resulting in cellular senescence. Therefore, TL is in strong adverse linear correlation with aging. Mounting evidence supports the notion that telomeres and male/female infertility are in a close relationship, posing the biology of telomeres as a hot topic in the era of human-assisted reproduction. Specifically, the length of sperm telomeres is gradually increasing as men get older, while the telomere length of the oocytes seems not to follow similar patterns with that of sperm. Nonetheless, the telomere length of the embryos during the cleavage stages seems to have a paternal origin, but the telomere length can be further extended by telomerase activity during the blastocyst stage. The latter has been proposed as a new molecular biomarker with strong predictive value regarding male infertility. As far as the role of telomeres in assisted reproduction, the data is limited but the length of telomeres in both gametes seems to be affected mainly by the cause of infertility rather than the assisted reproductive therapy (ART) procedure itself. The present review aims to shed more light into the role of telomeres in human embryological parameters, including gametes and embryos and also presents opinions regarding the association between telomeres and in vitro fertilization (IVF). |
format | Online Article Text |
id | pubmed-8628962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86289622021-11-30 Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF Anifandis, George Samara, Maria Simopoulou, Mara Messini, Christina I. Chatzimeletiou, Katerina Thodou, Eleni Daponte, Alexandros Georgiou, Ioannis J Dev Biol Review Telomeres promote genome integrity by protecting chromosome ends from the activation of the DNA damage response and protecting chromosomes from the loss of coding sequences due to the end replication problem. Telomere length (TL) is progressively shortened as age progresses, thus resulting in cellular senescence. Therefore, TL is in strong adverse linear correlation with aging. Mounting evidence supports the notion that telomeres and male/female infertility are in a close relationship, posing the biology of telomeres as a hot topic in the era of human-assisted reproduction. Specifically, the length of sperm telomeres is gradually increasing as men get older, while the telomere length of the oocytes seems not to follow similar patterns with that of sperm. Nonetheless, the telomere length of the embryos during the cleavage stages seems to have a paternal origin, but the telomere length can be further extended by telomerase activity during the blastocyst stage. The latter has been proposed as a new molecular biomarker with strong predictive value regarding male infertility. As far as the role of telomeres in assisted reproduction, the data is limited but the length of telomeres in both gametes seems to be affected mainly by the cause of infertility rather than the assisted reproductive therapy (ART) procedure itself. The present review aims to shed more light into the role of telomeres in human embryological parameters, including gametes and embryos and also presents opinions regarding the association between telomeres and in vitro fertilization (IVF). MDPI 2021-11-13 /pmc/articles/PMC8628962/ /pubmed/34842724 http://dx.doi.org/10.3390/jdb9040049 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Anifandis, George Samara, Maria Simopoulou, Mara Messini, Christina I. Chatzimeletiou, Katerina Thodou, Eleni Daponte, Alexandros Georgiou, Ioannis Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF |
title | Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF |
title_full | Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF |
title_fullStr | Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF |
title_full_unstemmed | Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF |
title_short | Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF |
title_sort | insights into the role of telomeres in human embryological parameters. opinions regarding ivf |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628962/ https://www.ncbi.nlm.nih.gov/pubmed/34842724 http://dx.doi.org/10.3390/jdb9040049 |
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