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Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes

Background Diabetes mellitus (DM) is a decisive risk factor for severe illness in coronavirus disease 2019 (COVID-19). India is home to a large number of people with DM, and many of them were infected with COVID-19. It is critical to understand the impact of DM on mortality and other clinical outcom...

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Autores principales: Kantroo, Viny, Kanwar, Manjit S., Goyal, Piyush, Rosha, Deepak, Modi, Nikhil, Bansal, Avdhesh, Ansari, Athar Parvez, Wangnoo, Subhash Kumar, Sobti, Sanjay, Kansal, Sudha, Chawla, Rajesh, Jasuja, Sanjiv, Gupta, Ishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628982/
https://www.ncbi.nlm.nih.gov/pubmed/34842758
http://dx.doi.org/10.3390/medsci9040065
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author Kantroo, Viny
Kanwar, Manjit S.
Goyal, Piyush
Rosha, Deepak
Modi, Nikhil
Bansal, Avdhesh
Ansari, Athar Parvez
Wangnoo, Subhash Kumar
Sobti, Sanjay
Kansal, Sudha
Chawla, Rajesh
Jasuja, Sanjiv
Gupta, Ishan
author_facet Kantroo, Viny
Kanwar, Manjit S.
Goyal, Piyush
Rosha, Deepak
Modi, Nikhil
Bansal, Avdhesh
Ansari, Athar Parvez
Wangnoo, Subhash Kumar
Sobti, Sanjay
Kansal, Sudha
Chawla, Rajesh
Jasuja, Sanjiv
Gupta, Ishan
author_sort Kantroo, Viny
collection PubMed
description Background Diabetes mellitus (DM) is a decisive risk factor for severe illness in coronavirus disease 2019 (COVID-19). India is home to a large number of people with DM, and many of them were infected with COVID-19. It is critical to understand the impact of DM on mortality and other clinical outcomes of COVID-19 infection from this region. Aims The primary objective of our study was to analyze the mortality rate in people with DM infected with COVID-19. The secondary objectives were to assess the effect of various comorbidities on mortality and study the impact of DM on other clinical outcomes. Methods This is a retrospective study of COVID-19 infected patients admitted to a tertiary care hospital in north India in the early phase of the pandemic. Results Of the 1211 cases admitted, 19 were excluded because of incomplete data, and 1192 cases were finally considered for analysis. DM constituted 26.8% of total patients. The overall mortality rate was 6.1%, and the rate was 10.7% in the presence of diabetes (p < 0.01, OR 2.55). In univariate analysis, increased age, chronic kidney disease (CKD), coronary artery disease (CAD), stroke, and cancer were associated with mortality. On multiple logistic regression, the independent predictors of mortality were CAD, CKD, and cancer. Breathlessness and low SpO(2) at presentation, extensive involvement in CXR, and elevated ANC/ALC ratio were also significantly associated with mortality. Conclusions The presence of comorbidities such as DM, hypertension, CAD, CKD, and cancer strongly predict the risk of mortality in COVID-19 infection. Early triaging and aggressive therapy of patients with these comorbidities can optimize clinical outcomes.
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spelling pubmed-86289822021-11-30 Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes Kantroo, Viny Kanwar, Manjit S. Goyal, Piyush Rosha, Deepak Modi, Nikhil Bansal, Avdhesh Ansari, Athar Parvez Wangnoo, Subhash Kumar Sobti, Sanjay Kansal, Sudha Chawla, Rajesh Jasuja, Sanjiv Gupta, Ishan Med Sci (Basel) Article Background Diabetes mellitus (DM) is a decisive risk factor for severe illness in coronavirus disease 2019 (COVID-19). India is home to a large number of people with DM, and many of them were infected with COVID-19. It is critical to understand the impact of DM on mortality and other clinical outcomes of COVID-19 infection from this region. Aims The primary objective of our study was to analyze the mortality rate in people with DM infected with COVID-19. The secondary objectives were to assess the effect of various comorbidities on mortality and study the impact of DM on other clinical outcomes. Methods This is a retrospective study of COVID-19 infected patients admitted to a tertiary care hospital in north India in the early phase of the pandemic. Results Of the 1211 cases admitted, 19 were excluded because of incomplete data, and 1192 cases were finally considered for analysis. DM constituted 26.8% of total patients. The overall mortality rate was 6.1%, and the rate was 10.7% in the presence of diabetes (p < 0.01, OR 2.55). In univariate analysis, increased age, chronic kidney disease (CKD), coronary artery disease (CAD), stroke, and cancer were associated with mortality. On multiple logistic regression, the independent predictors of mortality were CAD, CKD, and cancer. Breathlessness and low SpO(2) at presentation, extensive involvement in CXR, and elevated ANC/ALC ratio were also significantly associated with mortality. Conclusions The presence of comorbidities such as DM, hypertension, CAD, CKD, and cancer strongly predict the risk of mortality in COVID-19 infection. Early triaging and aggressive therapy of patients with these comorbidities can optimize clinical outcomes. MDPI 2021-10-26 /pmc/articles/PMC8628982/ /pubmed/34842758 http://dx.doi.org/10.3390/medsci9040065 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kantroo, Viny
Kanwar, Manjit S.
Goyal, Piyush
Rosha, Deepak
Modi, Nikhil
Bansal, Avdhesh
Ansari, Athar Parvez
Wangnoo, Subhash Kumar
Sobti, Sanjay
Kansal, Sudha
Chawla, Rajesh
Jasuja, Sanjiv
Gupta, Ishan
Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes
title Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes
title_full Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes
title_fullStr Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes
title_full_unstemmed Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes
title_short Mortality and Clinical Outcomes among Patients with COVID-19 and Diabetes
title_sort mortality and clinical outcomes among patients with covid-19 and diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628982/
https://www.ncbi.nlm.nih.gov/pubmed/34842758
http://dx.doi.org/10.3390/medsci9040065
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