Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review

Congenital junctional ectopic tachycardia (CJET) is a rare tachyarrhythmia that remains difficult to manage, with suboptimal control in most cases. Here, we report literature research on the use of ivabradine in the treatment of pediatric junctional ectopic tachycardia (JET), both congenital and pos...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Marco, Giovanni Maria, De Nigris, Angelica, Pepe, Angela, Pagano, Annamaria, Di Nardo, Giangiacomo, Tipo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629013/
https://www.ncbi.nlm.nih.gov/pubmed/34842781
http://dx.doi.org/10.3390/pediatric13040074
_version_ 1784607119428812800
author Di Marco, Giovanni Maria
De Nigris, Angelica
Pepe, Angela
Pagano, Annamaria
Di Nardo, Giangiacomo
Tipo, Vincenzo
author_facet Di Marco, Giovanni Maria
De Nigris, Angelica
Pepe, Angela
Pagano, Annamaria
Di Nardo, Giangiacomo
Tipo, Vincenzo
author_sort Di Marco, Giovanni Maria
collection PubMed
description Congenital junctional ectopic tachycardia (CJET) is a rare tachyarrhythmia that remains difficult to manage, with suboptimal control in most cases. Here, we report literature research on the use of ivabradine in the treatment of pediatric junctional ectopic tachycardia (JET), both congenital and postoperative, and describe the successful use of ivabradine–flecainide association for CJET therapy resistant to other antiarrhythmic agents. This new drug combination was effective in completely suppressing JET. Ivabradine–flecainide combination may be considered a new therapeutic strategy of CJET with a satisfactory efficacy/tolerability ratio in patients resistant to conventional drug combinations.
format Online
Article
Text
id pubmed-8629013
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86290132021-11-30 Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review Di Marco, Giovanni Maria De Nigris, Angelica Pepe, Angela Pagano, Annamaria Di Nardo, Giangiacomo Tipo, Vincenzo Pediatr Rep Case Report Congenital junctional ectopic tachycardia (CJET) is a rare tachyarrhythmia that remains difficult to manage, with suboptimal control in most cases. Here, we report literature research on the use of ivabradine in the treatment of pediatric junctional ectopic tachycardia (JET), both congenital and postoperative, and describe the successful use of ivabradine–flecainide association for CJET therapy resistant to other antiarrhythmic agents. This new drug combination was effective in completely suppressing JET. Ivabradine–flecainide combination may be considered a new therapeutic strategy of CJET with a satisfactory efficacy/tolerability ratio in patients resistant to conventional drug combinations. MDPI 2021-11-23 /pmc/articles/PMC8629013/ /pubmed/34842781 http://dx.doi.org/10.3390/pediatric13040074 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Di Marco, Giovanni Maria
De Nigris, Angelica
Pepe, Angela
Pagano, Annamaria
Di Nardo, Giangiacomo
Tipo, Vincenzo
Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review
title Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review
title_full Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review
title_fullStr Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review
title_full_unstemmed Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review
title_short Ivabradine–Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review
title_sort ivabradine–flecainide as breakthrough drug combination for congenital junctional ectopic tachycardia: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629013/
https://www.ncbi.nlm.nih.gov/pubmed/34842781
http://dx.doi.org/10.3390/pediatric13040074
work_keys_str_mv AT dimarcogiovannimaria ivabradineflecainideasbreakthroughdrugcombinationforcongenitaljunctionalectopictachycardiaacasereportandliteraturereview
AT denigrisangelica ivabradineflecainideasbreakthroughdrugcombinationforcongenitaljunctionalectopictachycardiaacasereportandliteraturereview
AT pepeangela ivabradineflecainideasbreakthroughdrugcombinationforcongenitaljunctionalectopictachycardiaacasereportandliteraturereview
AT paganoannamaria ivabradineflecainideasbreakthroughdrugcombinationforcongenitaljunctionalectopictachycardiaacasereportandliteraturereview
AT dinardogiangiacomo ivabradineflecainideasbreakthroughdrugcombinationforcongenitaljunctionalectopictachycardiaacasereportandliteraturereview
AT tipovincenzo ivabradineflecainideasbreakthroughdrugcombinationforcongenitaljunctionalectopictachycardiaacasereportandliteraturereview

Ejemplares similares