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Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the deadly disease known as coronavirus disease 2019 (COVID-19) that has reached pandemic proportions. Currently, there is no definitive treatment for COVID-19, although many vaccines have been developed. The World Health O...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Healthcare
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629102/ https://www.ncbi.nlm.nih.gov/pubmed/34845662 http://dx.doi.org/10.1007/s40119-021-00248-0 |
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author | Shiravi, Amir Abbas Ardekani, Ali Sheikhbahaei, Erfan Heshmat-Ghahdarijani, Kiyan |
author_facet | Shiravi, Amir Abbas Ardekani, Ali Sheikhbahaei, Erfan Heshmat-Ghahdarijani, Kiyan |
author_sort | Shiravi, Amir Abbas |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the deadly disease known as coronavirus disease 2019 (COVID-19) that has reached pandemic proportions. Currently, there is no definitive treatment for COVID-19, although many vaccines have been developed. The World Health Organization has approved the safety and efficacy of the AstraZeneca/Oxford, Johnson and Johnson/Janssen (JnJ), Moderna, Pfizer/BioNTech, Sinopharm, and Sinovac vaccines so far. The approved formulations of AstraZeneca, JnJ, and Gam-COVID-vac (Sputnik V) contain DNA delivered within non-replicating recombinant adenovirus vector-based systems, while the Pfizer and Moderna vaccines utilize mRNA technology and lipid nanoparticle delivery systems. All of these vaccines encode production of the SARS-CoV-2 spike (S) protein, ultimately triggering immunity in the human body. COVID-19 causes several cardiovascular complications, such as arrhythmias, myocarditis, pericarditis, and venous thromboembolism. SARS-CoV-2 vaccines have been associated with rare, but sometimes fatal, cardiovascular side effects, which are the topics of this review. SARS-CoV-2 vaccines in general may cause thromboembolic events, such as cerebral vein thrombosis, and mRNA-based vaccines in particular may cause myocarditis/pericarditis, with the latter more likely to occur in younger adults after the second vaccination dose. Nevertheless, the advantages of these vaccines for ending the pandemic and/or decreasing the mortality rate outweigh any risk for the rare cardiovascular complications. |
format | Online Article Text |
id | pubmed-8629102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-86291022021-11-30 Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview Shiravi, Amir Abbas Ardekani, Ali Sheikhbahaei, Erfan Heshmat-Ghahdarijani, Kiyan Cardiol Ther Review Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the deadly disease known as coronavirus disease 2019 (COVID-19) that has reached pandemic proportions. Currently, there is no definitive treatment for COVID-19, although many vaccines have been developed. The World Health Organization has approved the safety and efficacy of the AstraZeneca/Oxford, Johnson and Johnson/Janssen (JnJ), Moderna, Pfizer/BioNTech, Sinopharm, and Sinovac vaccines so far. The approved formulations of AstraZeneca, JnJ, and Gam-COVID-vac (Sputnik V) contain DNA delivered within non-replicating recombinant adenovirus vector-based systems, while the Pfizer and Moderna vaccines utilize mRNA technology and lipid nanoparticle delivery systems. All of these vaccines encode production of the SARS-CoV-2 spike (S) protein, ultimately triggering immunity in the human body. COVID-19 causes several cardiovascular complications, such as arrhythmias, myocarditis, pericarditis, and venous thromboembolism. SARS-CoV-2 vaccines have been associated with rare, but sometimes fatal, cardiovascular side effects, which are the topics of this review. SARS-CoV-2 vaccines in general may cause thromboembolic events, such as cerebral vein thrombosis, and mRNA-based vaccines in particular may cause myocarditis/pericarditis, with the latter more likely to occur in younger adults after the second vaccination dose. Nevertheless, the advantages of these vaccines for ending the pandemic and/or decreasing the mortality rate outweigh any risk for the rare cardiovascular complications. Springer Healthcare 2021-11-29 2022-03 /pmc/articles/PMC8629102/ /pubmed/34845662 http://dx.doi.org/10.1007/s40119-021-00248-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Shiravi, Amir Abbas Ardekani, Ali Sheikhbahaei, Erfan Heshmat-Ghahdarijani, Kiyan Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview |
title | Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview |
title_full | Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview |
title_fullStr | Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview |
title_full_unstemmed | Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview |
title_short | Cardiovascular Complications of SARS-CoV-2 Vaccines: An Overview |
title_sort | cardiovascular complications of sars-cov-2 vaccines: an overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629102/ https://www.ncbi.nlm.nih.gov/pubmed/34845662 http://dx.doi.org/10.1007/s40119-021-00248-0 |
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