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Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
Soluble Angiotensin-Converting Enzyme 2 (ACE2) constitutes an attractive antiviral capable of targeting a wide range of coronaviruses utilizing ACE2 as their receptor. Here, using structure-guided approaches, we developed divalent ACE2 molecules by grafting the extracellular ACE2-domain onto a human...
Autores principales: | Chen, Yaozong, Sun, Lulu, Ullah, Irfan, Beaudoin-Bussières, Guillaume, Anand, Sai Priya, Hederman, Andrew P., Tolbert, William D., Sherburn, Rebekah, Nguyen, Dung N., Marchitto, Lorie, Ding, Shilei, Wu, Di, Luo, Yuhong, Gottumukkala, Suneetha, Moran, Sean, Kumar, Priti, Piszczek, Grzegorz, Mothes, Walther, Ackerman, Margaret E., Finzi, Andrés, Uchil, Pradeep D., Gonzalez, Frank J., Pazgier, Marzena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629194/ https://www.ncbi.nlm.nih.gov/pubmed/34845451 http://dx.doi.org/10.1101/2021.11.24.469776 |
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