Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

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Soluble Angiotensin-Converting Enzyme 2 (ACE2) constitutes an attractive antiviral capable of targeting a wide range of coronaviruses utilizing ACE2 as their receptor. Here, using structure-guided approaches, we developed divalent ACE2 molecules by grafting the extracellular ACE2-domain onto a human...

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Detalles Bibliográficos
Autores principales: Chen, Yaozong, Sun, Lulu, Ullah, Irfan, Beaudoin-Bussières, Guillaume, Anand, Sai Priya, Hederman, Andrew P., Tolbert, William D., Sherburn, Rebekah, Nguyen, Dung N., Marchitto, Lorie, Ding, Shilei, Wu, Di, Luo, Yuhong, Gottumukkala, Suneetha, Moran, Sean, Kumar, Priti, Piszczek, Grzegorz, Mothes, Walther, Ackerman, Margaret E., Finzi, Andrés, Uchil, Pradeep D., Gonzalez, Frank J., Pazgier, Marzena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629194/
https://www.ncbi.nlm.nih.gov/pubmed/34845451
http://dx.doi.org/10.1101/2021.11.24.469776
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