Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

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The current COVID-19 pandemic highlights the need for broad-spectrum antiviral therapeutics. Here we describe a new class of self-assembling immunostimulatory short duplex RNAs that potently induce production of type I and type III interferon (IFN-I and IFN-III), in a wide range of human cell types....

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Detalles Bibliográficos
Autores principales: Si, Longlong, Bai, Haiqing, Oh, Crystal Yuri, Zhang, Tian, Hong, Fan, Jiang, Amanda, Ye, Yongxin, Jordan, Tristan X., Logue, James, McGrath, Marisa, Belgur, Chaitra, Nurani, Atiq, Cao, Wuji, Prantil-Baun, Rachelle, Gygi, Steven P, Powers, Rani K., Frieman, Matthew, tenOever, Benjamin R., Ingber, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629196/
https://www.ncbi.nlm.nih.gov/pubmed/34845453
http://dx.doi.org/10.1101/2021.11.19.469183
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