Cargando…

Protocol: Benefits and harms of remdesivir for COVID-19 in adults: A systematic review with meta-analysis

BACKGROUND: Effective drug treatments for Covid-19 are needed to decrease morbidity and mortality for the individual and to alleviate pressure on health care systems. Remdesivir showed promising results in early randomised trials but subsequently a large publicly funded trial has shown less favourab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paludan-Müller, Asger Sand, Lundh, Andreas, Page, Matthew J., Munkholm, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629254/ https://www.ncbi.nlm.nih.gov/pubmed/34843589 http://dx.doi.org/10.1371/journal.pone.0260544

Ejemplares similares

Considering the methodological limitations in the evidence base of antidepressants for depression: a reanalysis of a network meta-analysis
por: Munkholm, Klaus, et al.
Publicado: (2019)

Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review
por: Paludan-Müller, Asger Sand, et al.
Publicado: (2020)

Evaluation of benefits and harms of surgical treatments for post-radical prostatectomy urinary incontinence: a systematic review and meta-analysis protocol
por: Choiniere, Roselyne, et al.
Publicado: (2019)

The benefits and harms of therapeutic exercise on physical and psychosocial outcomes in people with multimorbidity: Protocol for a systematic review
por: Bricca, Alessio, et al.
Publicado: (2020)

Examining the benefits and harms of Alzheimer’s disease screening for family members of older adults: study protocol for a randomized controlled trial
por: Fowler, Nicole R., et al.
Publicado: (2020)

Clearing the air: protocol for a systematic meta-narrative review on the harms and benefits of e-cigarettes and vapour devices
por: MacDonald, Marjorie, et al.
Publicado: (2016)

The effect of information about the benefits and harms of mammography on women’s decision-making: study protocol for a randomized controlled trial
por: Carles, Misericòrdia, et al.
Publicado: (2017)

An evaluation of the benefits and harms of antenatal corticosteroid treatment for women at risk of imminent preterm birth or prior to elective Caesarean-section: Study protocol for an individual participant data meta-analysis
por: Wastnedge, Elizabeth, et al.
Publicado: (2020)

Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
por: Chuamanochan, Mati, et al.
Publicado: (2022)

Reporting of harms in oncological clinical study reports submitted to the European Medicines Agency compared to trial registries and publications—a methodological review
por: Paludan-Müller, Asger S., et al.
Publicado: (2021)

Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
por: Jørgensen, Caroline Kamp, et al.
Publicado: (2021)

Associations between humiliation, shame, self-harm and suicidal behaviours among adolescents and young adults: A systematic review protocol
por: McLoughlin, Aoibheann, et al.
Publicado: (2022)

Benefit-risk assessment for remdesivir in COVID-19
Publicado: (2020)

Evaluation of a Community Intervention to Reduce Harmful Alcohol Consumption among Adult Population: A Study Protocol
por: Porthé, Victoria, et al.
Publicado: (2022)

Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial
por: Wang, Yeming, et al.
Publicado: (2020)

Duloxetine versus ‘active’ placebo, placebo or no intervention for major depressive disorder; a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
por: Siddiqui, Faiza, et al.
Publicado: (2021)

Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
por: Hartman, Linda, et al.
Publicado: (2018)

Development of a checklist to detect errors in meta-analyses in systematic reviews of interventions: study protocol
por: Kanukula, Raju, et al.
Publicado: (2021)

Do protocols for new randomised trials take previous similar trials into account? Cohort study of contemporary trial protocols
por: Paludan-Müller, Asger Sand, et al.
Publicado: (2019)

The risks of adverse events with venlafaxine and mirtazapine versus ‘active placebo’, placebo, or no intervention for adults with major depressive disorder: a protocol for two separate systematic reviews with meta-analysis and Trial Sequential Analysis
por: Jørgensen, Caroline Kamp, et al.
Publicado: (2023)

Fall prevention interventions for older community-dwelling adults: systematic reviews on benefits, harms, and patient values and preferences
por: Pillay, Jennifer, et al.
Publicado: (2021)

Can an educational podcast improve the ability of parents of primary school children to assess the reliability of claims made about the benefits and harms of treatments: study protocol for a randomised controlled trial
por: Semakula, Daniel, et al.
Publicado: (2017)

Interdisciplinary intervention (GAIN) for adults with post-concussion symptoms: a study protocol for a stepped-wedge cluster randomised trial
por: Næss-Schmidt, Erhard Trillingsgaard, et al.
Publicado: (2022)

Randomized clinical trials with run-in periods: frequency, characteristics and reporting
por: Laursen, David Ruben Teindl, et al.
Publicado: (2019)

What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420)
por: French, David P., et al.
Publicado: (2020)

Rates and predictors of data and code sharing in the medical and health sciences: Protocol for a systematic review and individual participant data meta-analysis.
por: Hamilton, Daniel G., et al.
Publicado: (2021)

Remdesivir use in severe renal impairment: benefits outweigh risks
Publicado: (2021)

Harms associated with gambling: abbreviated systematic review protocol
por: Beynon, Caryl, et al.
Publicado: (2020)

Physical activity promotion for multimorbid patients in primary care settings: a protocol for a systematic review evaluating health benefits and harms
por: Schweda, Simone, et al.
Publicado: (2020)

Community Outpatient Psychotherapy Engagement Service for Self-harm (COPESS): a feasibility trial protocol
por: Saini, Pooja, et al.
Publicado: (2021)

Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial
por: Rodgers, Jacqui, et al.
Publicado: (2023)

“More air—better performance—faster recovery”: study protocol for randomised controlled trial of the effect of post-stroke inspiratory muscle training for adults
por: Sørensen, Susanne Lillelund, et al.
Publicado: (2021)

Classification of Patients for Whom Benefit of Long-term Opioid Therapy No Longer Outweighs Harm: Protocol for a Delphi Study
por: Van Cleve, Raymond, et al.
Publicado: (2022)

Dietary intake and risk of asthma in children and adults: protocol for a systematic review and meta-analysis
por: Garcia-Larsen, Vanessa, et al.
Publicado: (2016)

Physical and motivational effects of Exergames in healthy adults—Protocol for a systematic review and meta-analysis
por: Hoffmann, Katrin, et al.
Publicado: (2022)

Outcomes of usual chiropractic, harm & efficacy, the ouch study: study protocol for a randomized controlled trial
por: Walker, Bruce F, et al.
Publicado: (2011)

Study protocol for the implementation and evaluation of the Self-harm Assessment and Management for General Hospitals programme in Ireland (SAMAGH)
por: Arensman, Ella, et al.
Publicado: (2020)

Biomarkers, Clinical Course, and Individual Needs in COPD Patients in Primary Care: The Study Protocol of the Stockholm COPD Inflammation Cohort (SCOPIC)
por: Lundh, Lena, et al.
Publicado: (2022)

Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis
por: Piscoya, Alejandro, et al.
Publicado: (2020)

Cancer symptom clusters in adult patients undergoing chemotherapy: A systematic review and meta-analysis protocol
por: Lopes-Júnior, Luís Carlos, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5145bhqf7fjrf4hli46eugboo3