A brief review on DNA vaccines in the era of COVID-19

This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design strategies are described, then specific issues related to the industrial production of DNA vaccines are discussed, including the production and purification of DNA products such as plasmid DNA, minicircle DNA...

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Detalles Bibliográficos
Autores principales: Shafaati, Maryam, Saidijam, Massoud, Soleimani, Meysam, Hazrati, Fereshte, Mirzaei, Rasoul, Amirheidari, Bagher, Tanzadehpanah, Hamid, Karampoor, Sajad, Kazemi, Sima, Yavari, Bahram, Mahaki, Hanie, Safaei, Mohsen, Rahbarizadeh, Fatemeh, Samadi, Pouria, Ahmadyousefi, Yaghoub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629371/
https://www.ncbi.nlm.nih.gov/pubmed/34858516
http://dx.doi.org/10.2217/fvl-2021-0170
Descripción
Sumario:This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design strategies are described, then specific issues related to the industrial production of DNA vaccines are discussed, including the production and purification of DNA products such as plasmid DNA, minicircle DNA, minimalistic, immunologically defined gene expression (MIDGE) and Doggybone™. The use of adjuvants to enhance the immunogenicity of DNA vaccines is then discussed. In addition, different delivery routes and several physical and chemical methods to increase the efficacy of DNA delivery into cells are explained. Recent preclinical and clinical trials of DNA vaccines for COVID-19 are then summarized. Lastly, the advantages and obstacles of DNA vaccines are discussed.

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