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Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage

The accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is required for most of these interactions. For example,...

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Detalles Bibliográficos
Autores principales:	Zhao, Zhe, Fagerlund, Riku, Tossavainen, Helena, Hopfensperger, Kristina, Lotke, Rishikesh, Srinivasachar Badarinarayan, Smitha, Kirchhoff, Frank, Permi, Perttu, Sato, Kei, Sauter, Daniel, Saksela, Kalle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629392/ https://www.ncbi.nlm.nih.gov/pubmed/34780577 http://dx.doi.org/10.1371/journal.ppat.1009728

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