TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

PURPOSE: To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. METHODS: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. RESULTS: There was a...

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Detalles Bibliográficos
Autores principales: Peralta, Estela Morales, Rosales, Yaíma Zúñiga, Mesa, Teresa Collazo, González, Elvia Nelmi Santos, Pérez, Yadira Hernández, de los Ángeles González Torres, María, Balbuena, Hilda Roblejo, Teruel, Beatriz Marcheco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629595/
http://dx.doi.org/10.1186/s43042-021-00206-4
Descripción
Sumario:PURPOSE: To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. METHODS: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. RESULTS: There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. CONCLUSION: There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.

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