TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

PURPOSE: To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. METHODS: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. RESULTS: There was a...

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Autores principales: Peralta, Estela Morales, Rosales, Yaíma Zúñiga, Mesa, Teresa Collazo, González, Elvia Nelmi Santos, Pérez, Yadira Hernández, de los Ángeles González Torres, María, Balbuena, Hilda Roblejo, Teruel, Beatriz Marcheco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629595/
http://dx.doi.org/10.1186/s43042-021-00206-4
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author Peralta, Estela Morales
Rosales, Yaíma Zúñiga
Mesa, Teresa Collazo
González, Elvia Nelmi Santos
Pérez, Yadira Hernández
de los Ángeles González Torres, María
Balbuena, Hilda Roblejo
Teruel, Beatriz Marcheco
author_facet Peralta, Estela Morales
Rosales, Yaíma Zúñiga
Mesa, Teresa Collazo
González, Elvia Nelmi Santos
Pérez, Yadira Hernández
de los Ángeles González Torres, María
Balbuena, Hilda Roblejo
Teruel, Beatriz Marcheco
author_sort Peralta, Estela Morales
collection PubMed
description PURPOSE: To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. METHODS: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. RESULTS: There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. CONCLUSION: There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.
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spelling pubmed-86295952021-11-30 TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients Peralta, Estela Morales Rosales, Yaíma Zúñiga Mesa, Teresa Collazo González, Elvia Nelmi Santos Pérez, Yadira Hernández de los Ángeles González Torres, María Balbuena, Hilda Roblejo Teruel, Beatriz Marcheco Egypt J Med Hum Genet Correspondence PURPOSE: To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. METHODS: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. RESULTS: There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. CONCLUSION: There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients. Springer Berlin Heidelberg 2021-11-30 2021 /pmc/articles/PMC8629595/ http://dx.doi.org/10.1186/s43042-021-00206-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Correspondence
Peralta, Estela Morales
Rosales, Yaíma Zúñiga
Mesa, Teresa Collazo
González, Elvia Nelmi Santos
Pérez, Yadira Hernández
de los Ángeles González Torres, María
Balbuena, Hilda Roblejo
Teruel, Beatriz Marcheco
TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_full TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_fullStr TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_full_unstemmed TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_short TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_sort taqi polymorphism of the vdr gene: aspects related to the clinical behavior of covid-19 in cuban patients
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629595/
http://dx.doi.org/10.1186/s43042-021-00206-4
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