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Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study

BACKGROUND: Little is known about the role of cytokeratin 17 (CK17) during oral carcinogenesis. CK17 expression in oral leukoplakia (OL), the most encountered oral potentially malignant disorders and oral squamous cell carcinoma (OSCC), remains very limited. To determine the role of CK17 during oral...

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Autores principales: Sanguansin, Sirima, Kosanwat, Theerachai, Juengsomjit, Rachai, Poomsawat, Sopee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629611/
https://www.ncbi.nlm.nih.gov/pubmed/34853592
http://dx.doi.org/10.1155/2021/4089549
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author Sanguansin, Sirima
Kosanwat, Theerachai
Juengsomjit, Rachai
Poomsawat, Sopee
author_facet Sanguansin, Sirima
Kosanwat, Theerachai
Juengsomjit, Rachai
Poomsawat, Sopee
author_sort Sanguansin, Sirima
collection PubMed
description BACKGROUND: Little is known about the role of cytokeratin 17 (CK17) during oral carcinogenesis. CK17 expression in oral leukoplakia (OL), the most encountered oral potentially malignant disorders and oral squamous cell carcinoma (OSCC), remains very limited. To determine the role of CK17 during oral carcinogenesis and its potential diagnostic marker in oral premalignant and malignant lesions, this study evaluated CK17 expression in OL without dysplasia, OL with dysplasia, and OSCC. CK17 expression in these tissues was compared with those of normal oral mucosa (NOM). Additionally, the relationship between CK17 expression and clinicopathologic factors of OSCC was investigated. METHODS: CK17 expression was evaluated in 186 samples consisting of 12 NOM, 33 OL without dysplasia, 58 OL with dysplasia, and 83 OSCC using immunohistochemistry. The proportion of positively immunostained cells was evaluated and scored. RESULTS: CK17 was expressed in 8.3%, 54.5%, 74.1%, and 90.4% of NOM, OL without dysplasia, OL with dysplasia, and OSCC, respectively. NOM had a significantly lower CK17 score than OL with dysplasia (p=0.0003) and OSCC (p < 0.0001). A significant association between CK17 expression and histopathologic differentiation of OSCC was found. Tumors with well differentiation had high CK17 expression compared with those of moderate and poor differentiation. CONCLUSION: CK17 was overexpressed in OL with dysplasia and OSCC, suggesting that CK17 plays a pivotal role in the development of premalignant lesions and OSCC. Of clinical significance, CK17 may be a good diagnostic marker for oral premalignant lesions and OSCC. Additionally, CK17 could be used as an objective tool to classify histopathologic grade in OSCC. The findings that CK17 expression is high in OSCC but low in NOM imply that CK17 may serve as a potential therapeutic target for OSCC.
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spelling pubmed-86296112021-11-30 Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study Sanguansin, Sirima Kosanwat, Theerachai Juengsomjit, Rachai Poomsawat, Sopee Int J Dent Research Article BACKGROUND: Little is known about the role of cytokeratin 17 (CK17) during oral carcinogenesis. CK17 expression in oral leukoplakia (OL), the most encountered oral potentially malignant disorders and oral squamous cell carcinoma (OSCC), remains very limited. To determine the role of CK17 during oral carcinogenesis and its potential diagnostic marker in oral premalignant and malignant lesions, this study evaluated CK17 expression in OL without dysplasia, OL with dysplasia, and OSCC. CK17 expression in these tissues was compared with those of normal oral mucosa (NOM). Additionally, the relationship between CK17 expression and clinicopathologic factors of OSCC was investigated. METHODS: CK17 expression was evaluated in 186 samples consisting of 12 NOM, 33 OL without dysplasia, 58 OL with dysplasia, and 83 OSCC using immunohistochemistry. The proportion of positively immunostained cells was evaluated and scored. RESULTS: CK17 was expressed in 8.3%, 54.5%, 74.1%, and 90.4% of NOM, OL without dysplasia, OL with dysplasia, and OSCC, respectively. NOM had a significantly lower CK17 score than OL with dysplasia (p=0.0003) and OSCC (p < 0.0001). A significant association between CK17 expression and histopathologic differentiation of OSCC was found. Tumors with well differentiation had high CK17 expression compared with those of moderate and poor differentiation. CONCLUSION: CK17 was overexpressed in OL with dysplasia and OSCC, suggesting that CK17 plays a pivotal role in the development of premalignant lesions and OSCC. Of clinical significance, CK17 may be a good diagnostic marker for oral premalignant lesions and OSCC. Additionally, CK17 could be used as an objective tool to classify histopathologic grade in OSCC. The findings that CK17 expression is high in OSCC but low in NOM imply that CK17 may serve as a potential therapeutic target for OSCC. Hindawi 2021-11-22 /pmc/articles/PMC8629611/ /pubmed/34853592 http://dx.doi.org/10.1155/2021/4089549 Text en Copyright © 2021 Sirima Sanguansin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sanguansin, Sirima
Kosanwat, Theerachai
Juengsomjit, Rachai
Poomsawat, Sopee
Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study
title Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study
title_full Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study
title_fullStr Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study
title_full_unstemmed Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study
title_short Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study
title_sort diagnostic value of cytokeratin 17 during oral carcinogenesis: an immunohistochemical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629611/
https://www.ncbi.nlm.nih.gov/pubmed/34853592
http://dx.doi.org/10.1155/2021/4089549
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