Cargando…
Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B
BACKGROUND: The liver is the primary organ for amino acid metabolism, and metabolic disorder of amino acids is common in liver disease. However, the characteristics of plasma amino acid profiles in patients with HBV-related cirrhosis and the impacts of late-evening snack (LES) on cirrhosis are uncle...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629637/ https://www.ncbi.nlm.nih.gov/pubmed/34853787 http://dx.doi.org/10.1155/2021/1074565 |
_version_ | 1784607250990497792 |
---|---|
author | Hou, Wei Lv, Zheng Yang, Jing Wu, Jing Wang, Zhong-ying Meng, Qing-hua |
author_facet | Hou, Wei Lv, Zheng Yang, Jing Wu, Jing Wang, Zhong-ying Meng, Qing-hua |
author_sort | Hou, Wei |
collection | PubMed |
description | BACKGROUND: The liver is the primary organ for amino acid metabolism, and metabolic disorder of amino acids is common in liver disease. However, the characteristics of plasma amino acid profiles in patients with HBV-related cirrhosis and the impacts of late-evening snack (LES) on cirrhosis are unclear. OBJECTIVES: To investigate the characteristics of plasma amino acid profiles in patients with HBV-related chronic hepatitis, cirrhosis, and the effects of late-evening snacks on plasma amino acid profiles. METHODS: 86 patients with HBV-related cirrhosis and eighty patients with chronic hepatitis B were included in this study. The plasma amino acid profiles were measured by the amino acid analyzer. Patients were randomly divided into two groups, of which the liver cirrhosis group was to receive daily LES (n = 43) or non-LES (n = 43) for 6 months. Plasma amino acid profiles and biochemical parameters were measured in both groups at baseline and after 1, 3, and 6 months. RESULTS: Compared to healthy controls, the plasma concentration in the liver cirrhosis group of threonine, serine, glycine, glutamine, cysteine, tyrosine, phenylalanine, arginine, and methionine increased significantly (P < 0.05), while the ratio of branched chain amino acids (BCAA) to aromatic amino acids (AAA) decreased significantly (P < 0.05). A carbohydrate-predominant LES treatment resulted in a significant increase in BCAA/AAA and decrease in the level of ammonia and glutamine compared with baseline after 6 months of supplementation (P < 0.05). Patients with Child-Pugh B and C are more responsive to changes in amino acid profiles than those with Child-Pugh A. CONCLUSIONS: The application of an LES carbohydrate module for six months in liver cirrhosis patients was associated with increased BCAA/AAA and decreased level of ammonia. Patients with Child-Pugh B and C grades were the most beneficial population. |
format | Online Article Text |
id | pubmed-8629637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-86296372021-11-30 Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B Hou, Wei Lv, Zheng Yang, Jing Wu, Jing Wang, Zhong-ying Meng, Qing-hua Biomed Res Int Research Article BACKGROUND: The liver is the primary organ for amino acid metabolism, and metabolic disorder of amino acids is common in liver disease. However, the characteristics of plasma amino acid profiles in patients with HBV-related cirrhosis and the impacts of late-evening snack (LES) on cirrhosis are unclear. OBJECTIVES: To investigate the characteristics of plasma amino acid profiles in patients with HBV-related chronic hepatitis, cirrhosis, and the effects of late-evening snacks on plasma amino acid profiles. METHODS: 86 patients with HBV-related cirrhosis and eighty patients with chronic hepatitis B were included in this study. The plasma amino acid profiles were measured by the amino acid analyzer. Patients were randomly divided into two groups, of which the liver cirrhosis group was to receive daily LES (n = 43) or non-LES (n = 43) for 6 months. Plasma amino acid profiles and biochemical parameters were measured in both groups at baseline and after 1, 3, and 6 months. RESULTS: Compared to healthy controls, the plasma concentration in the liver cirrhosis group of threonine, serine, glycine, glutamine, cysteine, tyrosine, phenylalanine, arginine, and methionine increased significantly (P < 0.05), while the ratio of branched chain amino acids (BCAA) to aromatic amino acids (AAA) decreased significantly (P < 0.05). A carbohydrate-predominant LES treatment resulted in a significant increase in BCAA/AAA and decrease in the level of ammonia and glutamine compared with baseline after 6 months of supplementation (P < 0.05). Patients with Child-Pugh B and C are more responsive to changes in amino acid profiles than those with Child-Pugh A. CONCLUSIONS: The application of an LES carbohydrate module for six months in liver cirrhosis patients was associated with increased BCAA/AAA and decreased level of ammonia. Patients with Child-Pugh B and C grades were the most beneficial population. Hindawi 2021-11-22 /pmc/articles/PMC8629637/ /pubmed/34853787 http://dx.doi.org/10.1155/2021/1074565 Text en Copyright © 2021 Wei Hou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hou, Wei Lv, Zheng Yang, Jing Wu, Jing Wang, Zhong-ying Meng, Qing-hua Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B |
title | Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B |
title_full | Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B |
title_fullStr | Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B |
title_full_unstemmed | Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B |
title_short | Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B |
title_sort | long-term carbohydrate-containing late-evening snack significantly improves the ratio of branched chain amino acids to aromatic amino acids in adults with liver cirrhosis due to hepatitis b |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629637/ https://www.ncbi.nlm.nih.gov/pubmed/34853787 http://dx.doi.org/10.1155/2021/1074565 |
work_keys_str_mv | AT houwei longtermcarbohydratecontaininglateeveningsnacksignificantlyimprovestheratioofbranchedchainaminoacidstoaromaticaminoacidsinadultswithlivercirrhosisduetohepatitisb AT lvzheng longtermcarbohydratecontaininglateeveningsnacksignificantlyimprovestheratioofbranchedchainaminoacidstoaromaticaminoacidsinadultswithlivercirrhosisduetohepatitisb AT yangjing longtermcarbohydratecontaininglateeveningsnacksignificantlyimprovestheratioofbranchedchainaminoacidstoaromaticaminoacidsinadultswithlivercirrhosisduetohepatitisb AT wujing longtermcarbohydratecontaininglateeveningsnacksignificantlyimprovestheratioofbranchedchainaminoacidstoaromaticaminoacidsinadultswithlivercirrhosisduetohepatitisb AT wangzhongying longtermcarbohydratecontaininglateeveningsnacksignificantlyimprovestheratioofbranchedchainaminoacidstoaromaticaminoacidsinadultswithlivercirrhosisduetohepatitisb AT mengqinghua longtermcarbohydratecontaininglateeveningsnacksignificantlyimprovestheratioofbranchedchainaminoacidstoaromaticaminoacidsinadultswithlivercirrhosisduetohepatitisb |