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Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience

Due to the infection by the SARS-CoV-2 virus (COVID-19) there were also reported neurological symptoms, being the most frequent and best cited those that affect the cerebrovascular, sensorial, cognitive and motor functions, together with the neurological diffuse symptoms as for examples headache or...

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Autores principales: Sarubbo, Fiorella, El Haji, Khaoulah, Vidal-Balle, Aina, Bargay Lleonart, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629776/
https://www.ncbi.nlm.nih.gov/pubmed/34870247
http://dx.doi.org/10.1016/j.bbih.2021.100399
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author Sarubbo, Fiorella
El Haji, Khaoulah
Vidal-Balle, Aina
Bargay Lleonart, Joan
author_facet Sarubbo, Fiorella
El Haji, Khaoulah
Vidal-Balle, Aina
Bargay Lleonart, Joan
author_sort Sarubbo, Fiorella
collection PubMed
description Due to the infection by the SARS-CoV-2 virus (COVID-19) there were also reported neurological symptoms, being the most frequent and best cited those that affect the cerebrovascular, sensorial, cognitive and motor functions, together with the neurological diffuse symptoms as for examples headache or dizziness. Besides, some of them behave high risk of mortality. Consequently, it is crucial to elucidate the mechanisms of action in brain of SARS-CoV-2 virus in order to create new therapeutic targets to fight against this new disease. Since now the mechanisms of arrival to the brain seems to be related with the following processes: blood brain barrier (BBB) disruption together with nervous or axonal transport of the virus by the trigeminal nerve, the vagus nerve, or the brain-gut-axis. Being two the mechanisms of brain affectation most cited: a direct affectation of the virus in the brain through neuroinvasion and an indirect mechanism of action due to the effects of the systemic infection. Both processes include the triggering of inflammation, hypoxia and the increased likelihood of secondary infections. This topic supposes a major novel challenge for neuroscience. Therefore, the aim of this review is to provide summarized information about the neurological symptomatology and the brain pathogenic mechanisms involved and reported in COVID-19.
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spelling pubmed-86297762021-11-30 Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience Sarubbo, Fiorella El Haji, Khaoulah Vidal-Balle, Aina Bargay Lleonart, Joan Brain Behav Immun Health Review Due to the infection by the SARS-CoV-2 virus (COVID-19) there were also reported neurological symptoms, being the most frequent and best cited those that affect the cerebrovascular, sensorial, cognitive and motor functions, together with the neurological diffuse symptoms as for examples headache or dizziness. Besides, some of them behave high risk of mortality. Consequently, it is crucial to elucidate the mechanisms of action in brain of SARS-CoV-2 virus in order to create new therapeutic targets to fight against this new disease. Since now the mechanisms of arrival to the brain seems to be related with the following processes: blood brain barrier (BBB) disruption together with nervous or axonal transport of the virus by the trigeminal nerve, the vagus nerve, or the brain-gut-axis. Being two the mechanisms of brain affectation most cited: a direct affectation of the virus in the brain through neuroinvasion and an indirect mechanism of action due to the effects of the systemic infection. Both processes include the triggering of inflammation, hypoxia and the increased likelihood of secondary infections. This topic supposes a major novel challenge for neuroscience. Therefore, the aim of this review is to provide summarized information about the neurological symptomatology and the brain pathogenic mechanisms involved and reported in COVID-19. Elsevier 2021-11-30 /pmc/articles/PMC8629776/ /pubmed/34870247 http://dx.doi.org/10.1016/j.bbih.2021.100399 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Sarubbo, Fiorella
El Haji, Khaoulah
Vidal-Balle, Aina
Bargay Lleonart, Joan
Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience
title Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience
title_full Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience
title_fullStr Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience
title_full_unstemmed Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience
title_short Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience
title_sort neurological consequences of covid-19 and brain related pathogenic mechanisms: a new challenge for neuroscience
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629776/
https://www.ncbi.nlm.nih.gov/pubmed/34870247
http://dx.doi.org/10.1016/j.bbih.2021.100399
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