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Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho
OBJECTIVE: Earlobe crease (ELC) has been considered as a skin sign of atherosclerosis, and its pathophysiological mechanism is still unclear. Our study aims to test the hypothesis that ELC patients with lower serum levels of the age-suppressing hormone Klotho, which is not only associated with prema...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629917/ https://www.ncbi.nlm.nih.gov/pubmed/34858047 http://dx.doi.org/10.2147/IJGM.S300309 |
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author | Wang, Jian Zhu, Zhan-Fang Liu, Fu-Qiang Liu, Cun Ou-Yang, Ai-Mei Chen, Wei-Wei Wang, En-Guo Wang, Xi-Ming |
author_facet | Wang, Jian Zhu, Zhan-Fang Liu, Fu-Qiang Liu, Cun Ou-Yang, Ai-Mei Chen, Wei-Wei Wang, En-Guo Wang, Xi-Ming |
author_sort | Wang, Jian |
collection | PubMed |
description | OBJECTIVE: Earlobe crease (ELC) has been considered as a skin sign of atherosclerosis, and its pathophysiological mechanism is still unclear. Our study aims to test the hypothesis that ELC patients with lower serum levels of the age-suppressing hormone Klotho, which is not only associated with premature aging but also with endothelial dysfunction, may be associated with atherosclerosis. METHODS: A total of 135 patients aged 40–68 years underwent coronary angiography. According to the presence or absence of coronary heart disease (CAD) and ELC, they were divided into three groups: CAD group and ELC group (ELC group, n = 45); no ELC group (non-ELC group, n = 45). There was no ELC or CAD in the control group (control group, n = 45). Serum Klotho concentration was obtained by enzyme-linked immunosorbent assay (ELISA). RESULTS: The Klotho level in the ELC group was 365.6 ± 38.1 pg/mL, while the Klotho level in the non-ELC group was 568.8 ± 44.9 pg/mL. It is worth noting that the Klotho level of the ELC group was significantly lower than that of the non-ELC group (P < 0.001). The serum Klotho level of the control group was higher than that of the non-ELC group (593.3±45.3 vs 568.8±44.9 pg/mL, P = 0.702), but the difference was not statistically significant. Multiple logistic regression analysis showed that the Klotho level is a parameter that affects the appearance of ELC. CONCLUSION: Serum Klotho levels were considerably lower in patients with ELC. We concluded that the perturbations of Klotho in patients might be associated with ELC and with CAD. |
format | Online Article Text |
id | pubmed-8629917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-86299172021-12-01 Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho Wang, Jian Zhu, Zhan-Fang Liu, Fu-Qiang Liu, Cun Ou-Yang, Ai-Mei Chen, Wei-Wei Wang, En-Guo Wang, Xi-Ming Int J Gen Med Original Research OBJECTIVE: Earlobe crease (ELC) has been considered as a skin sign of atherosclerosis, and its pathophysiological mechanism is still unclear. Our study aims to test the hypothesis that ELC patients with lower serum levels of the age-suppressing hormone Klotho, which is not only associated with premature aging but also with endothelial dysfunction, may be associated with atherosclerosis. METHODS: A total of 135 patients aged 40–68 years underwent coronary angiography. According to the presence or absence of coronary heart disease (CAD) and ELC, they were divided into three groups: CAD group and ELC group (ELC group, n = 45); no ELC group (non-ELC group, n = 45). There was no ELC or CAD in the control group (control group, n = 45). Serum Klotho concentration was obtained by enzyme-linked immunosorbent assay (ELISA). RESULTS: The Klotho level in the ELC group was 365.6 ± 38.1 pg/mL, while the Klotho level in the non-ELC group was 568.8 ± 44.9 pg/mL. It is worth noting that the Klotho level of the ELC group was significantly lower than that of the non-ELC group (P < 0.001). The serum Klotho level of the control group was higher than that of the non-ELC group (593.3±45.3 vs 568.8±44.9 pg/mL, P = 0.702), but the difference was not statistically significant. Multiple logistic regression analysis showed that the Klotho level is a parameter that affects the appearance of ELC. CONCLUSION: Serum Klotho levels were considerably lower in patients with ELC. We concluded that the perturbations of Klotho in patients might be associated with ELC and with CAD. Dove 2021-11-25 /pmc/articles/PMC8629917/ /pubmed/34858047 http://dx.doi.org/10.2147/IJGM.S300309 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Wang, Jian Zhu, Zhan-Fang Liu, Fu-Qiang Liu, Cun Ou-Yang, Ai-Mei Chen, Wei-Wei Wang, En-Guo Wang, Xi-Ming Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho |
title | Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho |
title_full | Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho |
title_fullStr | Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho |
title_full_unstemmed | Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho |
title_short | Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho |
title_sort | patients with earlobe crease may associate with lower concentration of the age-suppressing hormone klotho |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629917/ https://www.ncbi.nlm.nih.gov/pubmed/34858047 http://dx.doi.org/10.2147/IJGM.S300309 |
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