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Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630013/ https://www.ncbi.nlm.nih.gov/pubmed/34845215 http://dx.doi.org/10.1038/s41541-021-00405-5 |
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| author | Zhong, Chaojie Xia, Hongjie Adam, Awadalkareem Wang, Binbin Hajnik, Renee L. Liang, Yuejin Rafael, Grace H. Zou, Jing Wang, Xiaofang Sun, Jiaren Soong, Lynn Barrett, Alan D. T. Weaver, Scott C. Shi, Pei-Yong Wang, Tian Hu, Haitao |
| author_facet | Zhong, Chaojie Xia, Hongjie Adam, Awadalkareem Wang, Binbin Hajnik, Renee L. Liang, Yuejin Rafael, Grace H. Zou, Jing Wang, Xiaofang Sun, Jiaren Soong, Lynn Barrett, Alan D. T. Weaver, Scott C. Shi, Pei-Yong Wang, Tian Hu, Haitao |
| author_sort | Zhong, Chaojie |
| collection | PubMed |
| description | A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine diminished viral loads and lung inflammation in mice after SARS-CoV-2 challenge, which correlated with the T-cell response induced by the vaccine in the lung, indicating that T-cell immunity is also likely critical for protection against SARS-CoV-2 infection in addition to neutralizing antibodies. |
| format | Online Article Text |
| id | pubmed-8630013 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86300132021-12-01 Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies Zhong, Chaojie Xia, Hongjie Adam, Awadalkareem Wang, Binbin Hajnik, Renee L. Liang, Yuejin Rafael, Grace H. Zou, Jing Wang, Xiaofang Sun, Jiaren Soong, Lynn Barrett, Alan D. T. Weaver, Scott C. Shi, Pei-Yong Wang, Tian Hu, Haitao NPJ Vaccines Brief Communication A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine diminished viral loads and lung inflammation in mice after SARS-CoV-2 challenge, which correlated with the T-cell response induced by the vaccine in the lung, indicating that T-cell immunity is also likely critical for protection against SARS-CoV-2 infection in addition to neutralizing antibodies. Nature Publishing Group UK 2021-11-29 /pmc/articles/PMC8630013/ /pubmed/34845215 http://dx.doi.org/10.1038/s41541-021-00405-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Zhong, Chaojie Xia, Hongjie Adam, Awadalkareem Wang, Binbin Hajnik, Renee L. Liang, Yuejin Rafael, Grace H. Zou, Jing Wang, Xiaofang Sun, Jiaren Soong, Lynn Barrett, Alan D. T. Weaver, Scott C. Shi, Pei-Yong Wang, Tian Hu, Haitao Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies |
| title | Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies |
| title_full | Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies |
| title_fullStr | Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies |
| title_full_unstemmed | Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies |
| title_short | Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies |
| title_sort | mucosal vaccination induces protection against sars-cov-2 in the absence of detectable neutralizing antibodies |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630013/ https://www.ncbi.nlm.nih.gov/pubmed/34845215 http://dx.doi.org/10.1038/s41541-021-00405-5 |
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